D-氨基葡萄糖混配金属络合物与脱氧核糖核酸作用的光谱分析  

Spectral Study on Some Metal Complexes Derived From D-Glucosamine Interaction With Deoxyribonucleic Acid

作　　者：叶勇[1] 胡继明[2] 沈昊宇[3] 乐芝凤[3] 

机构地区：[1]湖北大学化学系. [2]武汉大学分析测试科学系,武汉430072 [3]华中师范大学化学系,武汉430070

出　　处：《分析化学》1998年第6期709-714,共6页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金!(编号:29745001)

摘　　要：合成了４种Ｄ－氨基葡萄糖金属络合物，采用电子吸收光谱、荧光光谱、表面增强拉曼光谱对比研究了它们与ＤＮＡ作用，发现这４种化合物与ＤＮＡ的作用能力并不相同，Ｃｏ（Ⅲ）ＧｌｕＧ是值得进一步研究的可能抗癌药物．Some Metal Complexes that derived from D-glucosamine were synthesized. The effects of these compounds on deoxyribonucleic acid (DNA) have been studied by the UVVis, fluorescence and surface-enhanced Raman spectral method. Experiment results show that Co(Ⅲ)GluG has strong interactions with DNA. It is worthy to do a further research on these compounds as anticancer drugs.

关 键 词：D-氨基葡萄糖 氨基葡萄糖 配合物 DNA 相互作用 

分 类 号：Q523.02[生物学—生物化学]