^(188)W-^(188)Re发生器的研制  

DEVELOPMENT OF 188 W 188 Re GENERATOR

作　　者：盛荣[1] 李文新[1] 朱明花[1] 何蔚瑜[1] 尹端止[1] 胡伟青[1] 

机构地区：[1]中国科学院上海原子核研究所

出　　处：《核化学与放射化学》1998年第2期109-113,共5页Journal of Nuclear and Radiochemistry

基　　金：国家自然科学基金

摘　　要：以酸性氧化铝为吸附剂，制备了一个１１８ＭＢｑ的１８８Ｗ－１８８Ｒｅ发生器，并对发生器性能进行了为期４个月的检测。结果表明，１８８Ｒｅ的淋洗产额在８０％—９０％之间，１８８Ｗ的穿透率约为１．０×１０－４％。由于采用了较大高径比的交换柱，使１８８Ｒｅ的放射性比活度较高，能满足用于放射免疫治疗研究的抗肿瘤单克隆抗体标记的要求。An alumina based 188 W 188 Re generator,containing 188 MBq (3.2 mCi) 188 W,has been prepared.Performance of the generator has been evaluated for four months.The results indicated that the 188 Re yields of elution with physiological saline decreased from approximately 90% to around 80% and the breakthrough of the parent 188 W is about 1×10 -4 %.Due to the higher ratio of height to diameter of the chromatographic column employed in the work,higher specific acitivity of the 188 Re from the generator can meet the requirements of labeling monoclonal antibodies for radioimmunotherapy.

关 键 词：^188W ^188RE 发生器 ^188RE 铼188发生器 制备 

分 类 号：O614.713[理学—无机化学]