细胞型朊蛋白PrP^C与浮舰蛋白flotillin功能的研究进展  

Research progress regarding function of cellular prion protein PrP^C and lipid raft protein flotillin

作　　者：刘永生[1] 张杰[1] 马丽娜[1] 陈豪泰[1] 

机构地区：[1]中国农业科学院兰州兽医研究所/家畜疫病病原生物学国家重点实验室/农业部畜禽病毒学重点开放实验室/农业部兽医公共卫生重点开放实验室,兰州730046

出　　处：《中国农业大学学报》2009年第3期12-16,共5页Journal of China Agricultural University

基　　金：国家自然科学基金资助项目(30671563;30700597);甘肃省科技攻关重点资助项(2GS042-A41-001-09);甘肃省自然科学基金暨中青年科技基金项目(3ZS051-A25-065);国家博士后科学基金资助项目(20040350585)

摘　　要：朊蛋白和脂筏是当今研究的热点。细胞型朊蛋白(PrPC)能够通过构象转变生成致病型的朊病毒(PrPSc),导致海绵状脑病的发生,但是目前关于PrPC的转变机制还不清楚。PrPC也是重要的信号转导蛋白,引发众多的信号转导事件。Flotillin属于新被命名为SPFH(stomatin/prohibitin/flotillin/HflK/C)的蛋白家族,是重要的脂筏标识性蛋白,它们不仅被动地担当着非胞膜窖脂筏的脚架,为蛋白质的相互作用和蛋白质复合体的组装以及信号转导提供平台,而且本身还主动地扮演着信号蛋白的角色,在许多的细胞事件中发挥重要作用。PrPC与flotillin能够发生相互作用,flotillin蛋白为PrPC的跨膜信号转导和PrPC转变成PrPSc提供了环境。本文重点综述了近5年来关于PrPC和flotillin蛋白功能的研究进展,尤其是信号转导方面的研究。The prion protein and the lipid raft proteins are the current emphases. The normal cellular prion protein, PrPc , may lead to the occurrence of the spongiform encephalopathy by its transconformation PrP^Sc , the scrapie prion protein. However, the mechanism of how PrPc convert to PrP^Sc is unclear until now. PrPc is an important signal transduction protein, triggering a serial of signal transduction events. The flotillins belongs to the newly-named SPFH （stomatin/prohibitin/flotillin/HflK/C）protein family, and it is an important marker protein for lipid raft. Flotillins not only provides membrane platform for protein interaction acting as a scaffolding proteins, but also an important signaling protein participating numerous vital processes of the cell during assembly of the multiprotein complex and signal transduction. Flotillins can interact with PrPc and provide a platform for the transmembrane signal transduction of PrPc and the transconformation from PrPc to PrP^Sc. This paper reviewed the research progress in recent 5 years regarding the function of prpCand flotillins, especially the concern of the signal transduction.

关 键 词：浮舰蛋白 海绵状脑病 细胞型朊蛋白 信号转导 脂筏蛋白 

分 类 号：Q511[生物学—生物化学]