生物蛋白胶联合明胶海绵预防兔硬膜外黏连  

Bioprotein glue combined with gelatin sponge for prevention of epidural adhesions after surgical operation

作　　者：李彦明[1] 陈允震[1] 张科峰[2] 刘海春[1] 裴保安[1] 

机构地区：[1]山东大学齐鲁医院骨创科,山东济南250012 [2]山东大学第二医院骨外科,山东济南250033

出　　处：《基础医学与临床》2009年第6期622-626,共5页Basic and Clinical Medicine

摘　　要：目的观察可吸收性明胶海绵和生物蛋白胶联合应用在预防椎板切除术后硬膜外及神经根瘢痕黏连的作用。方法36只成年新西兰雄兔切除L6(第6腰椎)椎板,制作椎板切除模型,并探查神经根,根据应用材料不同随机分为3组:明胶海绵和生物蛋白胶组(A组)、明胶海绵(B组)、对照组(0.9%生理盐水)(C组)。术后第2、8周每组各处死6只,取标本行大体形态观察、神经根活动范围测量、及组织学观察。结果明胶海绵和生物蛋白胶联合应用组可显著预防黏连(P<0.05)。结论明胶海绵与生物蛋白胶联合应用能有效减轻硬脊膜及神经根与周围组织的瘢痕黏连。Objective To prove the prophylactic function of absorbable gelatin sponge and bioprotein glue for prevention of epidural and nerve root scar adhesions after laminectomy. Methods We excised the L6 vertebral plates of 36 adult New Zealand male rabbits, to make vertebral plate excision model and to find nerve root. Then divided them into 3 groups based on different materials： gelatin sponge and bioproten glue （group A）, gelatin sponge （group B） and saline solution （group C）. The morphological changes of the scars were observed grossly and histologically at 2 and 8 weeks after operation. We also measured the orbit of the nerve root. Results Gelatin sponge combining with bioprotein glue can reduce adhesion obviously （P 〈 0. 05 ）. Conclusion Gelatin sponge combining with bioprotein glue can allievate spinal dural mater and nerve root scar adhesions with surrounding tissue.

关 键 词：椎板切除术 明胶海绵 生物蛋白胶 硬膜外黏连 预防 

分 类 号：R687[医药卫生—骨科学]