歧化松香胺-壳聚糖缀合物的合成、表征及药控缓释行为  

Synthesis and characterization of disproportionated rosin amine-chitosan conjugate and its drug release behavior

作　　者：周龙昌[1] 段文贵[1] 申长茂[1] 岑波[1] 雷福厚 

机构地区：[1]广西大学化学化工学院,广西南宁530004 [2]广西林产化学品开发与应用重点实验室,广西南宁530006

出　　处：《化学研究与应用》2009年第6期833-838,共6页Chemical Research and Application

基　　金：广西科学基金资助项目(桂科自0640005);广西林产化学品开发与应用重点实验室开放基金资助项目(GXFC08-04)

摘　　要：以天然可再生资源壳聚糖和歧化松香胺为原料,经由苯甲醛保护氨基的Schiff碱壳聚糖,通过环氧氯丙烷搭桥生成具有环氧活性基的壳聚糖,再与歧化松香胺发生接枝反应,首次合成了一种新型壳聚糖衍生物——歧化松香胺-壳聚糖缀合物(DRACC),通过FT-IR、UV、1H-NMR、XRD、SEM和TG-DTA等测试手段对产物进行了分析和表征。由元素分析法测得DRACC的取代度为0.506。并分别以壳聚糖和DRACC作为药物非诺洛芬钙缓释制剂的载体,研究了其在人工肠液和人工胃液中的缓释性能。结果表明,DRACC载体在人工肠液和人工胃液中均具有良好的缓释作用。A new type of chitosan derivative, disproportionated rosin amine-chitosan conjugate （DRACC）, was synthesized by using chitosan and disproportionated rosin amine as raw materials for the first time. The target product was analyzed and characterized by means of FT-IR, UV,^1H-NMR, XRD, SEM and TG-DTA. The degree of substitution （DS） of DRACC was determined via elemental analysis to be 0. 506. Furthermore, chitosan and DRACC were used as carriers of fenoprofen calcium （ FC）, and their controlled release in artificial intestinal juice and in artificial gastric juice was studied. The results showed that the controlled release of FC from the carrier of DRACC was very good both in artificial intestinal juice and in artificial gastric juice.

关 键 词：壳聚糖 歧化松香胺 合成 缓释 

分 类 号：O631.1[理学—高分子化学]