间尼索地平分子模板聚合物的识别特性  

Characteristics of molecular recognition of m-nisoldipine template polymer

作　　者：贾评[1] 冯丽霞[2] 刘静[3] 修荣[3] 

机构地区：[1]河北北方学院第二附属医院药剂科,河北宣化075100 [2]河北医科大学外语部,河北石家庄050017 [3]河北医科大学药学院,河北石家庄050017

出　　处：《化学研究与应用》2009年第6期903-905,共3页Chemical Research and Application

基　　金：河北省科技厅重点资助项目(07276101D-37)

摘　　要：A molecular template synthetic polymer highly selective for m-nisoldipine was prepared by a molecular imprinting technique.The selective binding characteristics of the template polymer were evaluated by Scatchard analysis and ultraviolet spectrometry.The results showed that the its dissociation constant was estimated to beKd=1.523×10-3mmol/L.The selectivity binding experiment for substrates indicated the polymer gave a high affinity and selectivity for m-nisoldipine.A molecular template synthetic polymer highly selective for m-nisoldipine was prepared by a molecular imprinting technique. The selective binding characteristics of the template polymer were evaluated by Scatchard analysis and ultraviolet spectrometry. The results showed that the its dissociation constant was estimated to beKa = 1. 523 × 10^-3 mmol/Lo The selectivity binding experiment for substrates indicated the polymer gave a high affinity and selectivity for m-nisoldipine.

关 键 词：分子印迹聚合物 间尼索地平 底物选择性 分子识别 

分 类 号：O621.3[理学—有机化学]