桑牛强生胶囊对4.0Gy照射小鼠造血功能的影响  

The Effect of SN Qiangsheng Capsule on the Hematopoiesis of Mice.

作　　者：徐洁[1] 杨娟娟[2] 宁尚义[2] 岳林明[1] 姜枫勤[1] 

机构地区：[1]山东省医学科学院,山东济南250062 [2]山东省医学科学院放射医学研究所

出　　处：《中国辐射卫生》2009年第2期132-134,共3页Chinese Journal of Radiological Health

基　　金：山东省自然基金重点项目(Z2006C12)

摘　　要：目的观察桑牛强生胶囊(SN)对4.0Gy照射小鼠造血功能的保护作用。方法将小鼠随机分为正常对照组、环磷酰胺对照组、阿归对照组和药物大小剂量5个实验组。实验组小鼠以^(60)Coγ射线照射和给予环磷酰胺注射形成骨髓抑制模型,药物组给予不同剂量中药口服,正常对照组与环磷酰胺对照组给予生理盐水。实验前及实验后测体重,第7、14天检测血象,停药后的第2天,处死小鼠,观察骨髓有核细胞数。结果SN可使由于^(60)Coγ射线照射和环磷酰胺所致的Hb、RBC、WBC、PC减少明显提高,骨髓有核细胞数比环磷酰胺对照组明显增加,差异有统计学意义(P<0.05、P<0.01]。结论SN有显著刺激骨髓造血功能的作用,具有防治辐射损伤的作用。Objective To observe the hematopoietic protective effect caused by SN Qiangsheng Capsule on the pathological mice. Methods The mice were randomly derided into five experimental groups： the normal control group, the control group, the Egui control group and the drug dose size group. The experimental mice were irradiated with 60Co γand given injections of cyclophosphamide to make bone marrow suppression models. Drug group was given different doses of oral medicine, meanwhile, the normal control group and control group were given saline. The weights were measured before and after the experiment. The blood was tested on the 7th and the 14th day. On the second day of stopping using drug, the mice were killed and the nuclear bone marrow cells were counted. Results SN Qiangsheng Capsule would make the Hb, RBC, WBC and PC caused by 60Co γ radiation and cyclophosphamide reduced significantly, and the number of bone marrow cells increased more significantly than that of the control group. The differences were significant （ P 〈 0. 05 ） （ P 〈 0. 01 ）. Conclusions SN Qiangsheng Capsule can significantly stimulate the function of bone marrow, and have certain fundation of anti - radiation.

关 键 词：骨髓有核细胞 外周血象 60Coγ射线 环磷酰胺 桑叶多糖 牛磺酸 组配 

分 类 号：R818[医药卫生—放射医学]