恩诺沙星与磺胺间甲氧嘧啶联合药敏试验  

Susceptibility Testing of the Combination of Enrofloxacin and Sulfamonomethoxine

作　　者：郭永刚[1] 李荣誉[1] 周延州[1] 边传周[1] 

机构地区：[1]郑州牧业工程高等专科学校,郑州450011

出　　处：《中国兽药杂志》2009年第6期9-11,共3页Chinese Journal of Veterinary Drug

基　　金：河南省教育厅自然科学研究计划项目(项目编号2008B230005)

摘　　要：为研究氟喹诺酮类药物和磺胺类药物在治疗鸡大肠杆菌病时的相互作用,本试验采用肉汤稀释棋盘法,用恩诺沙星和磺胺间甲氧嘧啶对鸡致病性大肠杆菌进行了体外联合药敏试验。单药恩诺沙星和磺胺间甲氧嘧啶的最小抑菌浓度(MIC)分别为32、256μg/mL;联合用药的MIC分别为8μg/mL和32μg/mL,经计算FIC指数为0.375。结果表明,恩诺沙星与磺胺间甲氧嘧啶联合用药对大肠杆菌呈现协同抗菌作用。The study was conducted on the sensitivity of the pathogenic E. coli of chicken to enrofloxacin combined with sulfamonomethoxine. When enrofloxacin and sulfamonomethoxine was used alone, the MIC was 32 μg/mL, 256 μg/mL respectively, when the use of enrofloxacin and sulfamonomethoxine was combined, the MIC was 8 μg/mL,32 μg/mL respectively. The FIC was 0. 375. The result suggested that the combination of enrofloxacin and sulfamonomethoxine demonstrate synergic action on the bacteria.

关 键 词：恩诺沙星 磺胺间甲氧嘧啶 鸡致病性大肠杆菌 联合药敏试验 

分 类 号：S859.796[农业科学—临床兽医学]