糙海参中具有抗真菌活性的三萜皂苷(英文)  

Antifungal active triterpene glycosides from sea cucumber Holothuria scabra

作　　者：韩华[1,2] 易杨华[1] 李玲[1] 刘宝姝[1] 喇明平[1] 张宏伟[1] 

机构地区：[1]第二军医大学药学院海洋药物研究中心,上海200433 [2]浙江大学动物科学学院,浙江杭州310029

出　　处：《药学学报》2009年第6期620-624,共5页Acta Pharmaceutica Sinica

基　　金：Project supported by the “863” Hi-tech Research and Development Program of China (No2006AA09Z417) ;National Natural Science Foundation of China (No20772155)

摘　　要：为了研究糙海参体内的化学成分,寻找结构新颖具有抗真菌活性的三萜皂苷类成分。应用多种色谱分离技术对糙海参体内的化学成分进行分离纯化,根据化合物的理化性质、波谱数据及化学方法鉴定其结构。分离得到3个三萜皂苷化合物,分别为scabraside A(1)、echinoside A(2)和holothurin A1(3),并对其抗真菌活性进行了研究(1≤MIC80≤16μg·mL-1)。化合物1为新的三萜皂苷化合物,化合物2和3为首次从该海参中分离得到,它们均显示显著的抗真菌活性。To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A （1）, echinoside A （2） and holothurin A1 （3）. Scabraside A （1） is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities （1 ≤MIC80≤16 μg·mL^-1）.

关 键 词：糙海参 三萜皂苷 抗真菌活性 

分 类 号：R284.1[医药卫生—中药学]