聚β-环糊精缓释微球的热稳定性研究  

Study on Thermal Stability of Poly-β-CD Sustained Release Microspheres

作　　者：王晓明[1] 谭载友[1] 

机构地区：[1]广东药学院,广州510006

出　　处：《科学技术与工程》2009年第11期3054-3056,3062,共4页Science Technology and Engineering

摘　　要：为研究聚β-环糊精缓释微球的热稳定性及其热分解反应动力学参数,用热重法(TGA)和差示扫描量热法(DSC)。结果其热分解反应为一级动力学过程,表观活化能Ea为164.04kJ.mol-1(Kissinger法)或169.84kJ.mol-1(Ozawa法),指前因子A为1.05×1013,反应速率常数k298为2.69×10-15s-1,半衰期t209.58为8.18×106a。证明β-环糊精(β-CD)经聚合反应制成聚β-CD缓释微球后,其热稳定性显著提高。To investigate thermal stability of poly-β-CD sustained release microspheres and its kinetics analysis of thermal decomposition reaction, thermal gravity analysis （TGA） and differential scanning calorimetry （DSC） were used. Thermal decomposition reaction of poly-β-CD sustained release microspheres belonged to the first-order reaction. Its thermodynamics parameters were achieved： Ea = 164.04 kJ·mol^-1 （Kissinger） or 169.84 kJ·mol^-1 （Ozawa） ; A= 1.05×10^13 ; k298 =2.69×10^-15 s^-1 ; t0.5^298 = 8.18×10^6 year. It is concluded that Poly-β-CD sustained release microspheres had a better thermal stability than β-CD.

关 键 词：热重分析 差热分析 聚β-CD缓释微球 热稳定性 反应动力学 

分 类 号：R913[医药卫生—药学]