院内下呼吸道感染细菌耐药性及临床用药分析  

Analysis of Pathogenic Bacterial Drug Resistance and Clinical Medication in Lower Respiratory Tract Nosocomial Infection

作　　者：王涛[1] 吕冬梅[1] 邱述玲[1] 任玲[1] 周宏[1] 许美荣[1] 

机构地区：[1]徐州医学院附属医院,江苏徐州221002

出　　处：《抗感染药学》2009年第2期125-127,共3页Anti-infection Pharmacy

基　　金：江苏省卫生厅医学科技发展基金临床药学研究科技项目(No:P200508)

摘　　要：目的:了解院内下呼吸道感染患者病原菌耐药性及抗菌药物使用情况,为临床合理选择抗菌药物提供参考。方法:前瞻性调查2006年1月—2007年9月351例院内下呼吸道感染患者痰标本培养、分离及药敏试验,临床药师对228例病原菌监测阳性病例进行用药干预,分析病原菌耐药性及抗菌药物使用情况。结果:共检出致病微生物340株,其中:革兰阴性菌(65.88%)、革兰阳性菌(18.82%)、真菌(15.29%)。革兰阴性杆菌是下呼吸道感染的主要致病菌,细菌耐药性严重。结论:临床药师参与临床合理选用抗菌药物,减少了新的耐药菌株出现,提高了院内下呼吸道感染治疗有效率。Objective： To find out the pathogens drug resistance and antibiotics usage in lower respiratory tract infection and to provide a scientific basis for rational antibiotics usage. Methods： 351 patients with lower respiratory tract infections from Jan. 2006 to Sep. 2007 were reviewed prospectively in respect of the results of sputum culture and antimicrobial susceptibility. At the same time, the clinical pharmacists interfered in 228 patients and analyzed the drug resistance of pathogens and antibiotics usage. Results： A total of 340 strains were detected, of which, 65.90% were gram-negative bacteria, 18.80% were gram-positive bacteria, and 15.30% were fungi. Gram-negative bacteria were main pathogens in lower respiratory tract infection, Drug resistance was serious. Conclusion： The clinical pharmacists supervised clinicians to adjust antibiotics usage rationally. So we decreased the emergency of new drug resistance bacteria and raised the medication efficiency in lower respiratory tract infection.

关 键 词：院内下呼吸道感染 病原菌 耐药性 临床药师 

分 类 号：R969.3[医药卫生—药理学]