新型含糖氨基1,2,4-噻二唑类化合物的合成  

Synthesis of novel 5-glycosylamino-1,2,4-thiadiazoles

作　　者：杨金凤[1] 曹玲华[2] 

机构地区：[1]石河子大学化学化工学院,新疆石河子832003 [2]新疆大学化学化工学院,新疆乌鲁木齐830046

出　　处：《化学试剂》2009年第6期419-422,共4页Chemical Reagents

摘　　要：利用糖基异硫氰酸酯与异脲、异硫脲的亲核加成反应,设计合成了含有糖基修饰的硫脲衍生物,再用Br2氧化关环,得到了标题化合物。合成的12个化合物均为新化合物,未见文献报道,结构经IR1、HNMR、MS及元素分析进行确证。Glycosyhhioureas were synthesized after nucleophilic addition of the glycosyl isothiocyanates to isothioureas. These glycosylthioureas were further subjected to eyelization through oxidation with bromine to yield 3-alkyhhio-5-glyeosylamino-1,2, 4- thiadiazoles. All these compounds have not been reported yet and their structures were verified by 1R,^1HNMR and MS spectral data.

关 键 词：糖基异硫氰酸酯 1 2 4-噻二唑 合成 

分 类 号：O626.27[理学—有机化学]