阳离子表面活性剂增敏1,2-萘醌-4-磺酸钠光度法测定羧甲司坦  

Study of Sensitization of Cationic Surfactant for Spectrophotometric Determination of Carbocisteine with Sodium 1,2-Naphthoquinone-4-sulfonate

作　　者：吴云玲[1] 李全民[1] 

机构地区：[1]河南师范大学化学与环境科学学院,河南省环境污染控制重点实验室,新乡453007

出　　处：《应用化学》2009年第6期742-745,共4页Chinese Journal of Applied Chemistry

基　　金：河南省教育厅自然科学基金资助项目(2008B150011)

摘　　要：建立了1,2-萘醌-4-磺酸钠与羧甲司坦配合物生成光度法测定羧甲司坦的新方法。当控制溶液pH=11.0时,羧甲司坦、1,2-萘醌-4-磺酸钠与氯化十四烷基二甲基苄基铵生成摩尔比为1∶1∶1红褐色产物（λmax=466 nm）,表观摩尔吸光系数ε=2.2×10^3L/（mol.cm）。羧甲司坦质量浓度在0.72-28.67 mg/L内与吸光度呈良好线性关系,线性方程为：A=0.223 02＋0.011 98c（mg/L）,线性相关系数r=0.999 2,RSD和检测限分别为0.52%和0.70 mg/L,回收率98.7%-102.6%。该法能直接用于药物样品中羧甲司坦测定,结果满意。A new method was proposed for the determination of carbocisteine（S-CMC） with 1,2-naphthoquinone-4-sulfonate （NQS） by spectrophotometry. It was indicated that the molar ratio of the russety product formed by S-CMC, Zeph and NQS was 1 ： 1 ： 1 at pH = 11.00. The linear regression equation was A = 0. 223 02 ＋0. 011 98c（mg/L）, with a correlation coefficient of 0. 999 2, and 6 was 2.2 × 10^3 L/（mol · cm） at 466 nm. Beer＇s law was well obeyed in a S-CMC concentration range of 0. 72 - 28.67 mg/L. The limit of detection（3σ/κ） was 0. 70 mg/L, and the RSD was 0. 52% , and the average recovery rate was in a range of 98.7% - 102.6%. The method was used for the determination of S-CMC in pharmaceutical samples with satisfactory results.

关 键 词：羧甲司坦 萘醌磺酸钠 氯化十四烷基二甲基苄基铵 

分 类 号：O652.6[理学—分析化学]