夫西地酸在含果糖氯化钠溶液中的配伍稳定性考察  

Investigation of Compatible Stability of Fusidate Sodium for Injection in 0.9%Sodium Chloride Injection Containing Fructose Sodium

作　　者：李雪松[1] 钱斌[1] 杨龙[1] 李小军[1] 晏远志[1] 邹顺[1] 

机构地区：[1]昆明医学院第一附属医院药剂科,云南昆明650032

出　　处：《中国药业》2009年第12期22-23,共2页China Pharmaceuticals

摘　　要：目的考察夫西地酸在含果糖的0.9%氯化钠注射液中的稳定性。方法观察夫西地酸与果糖在氯化钠溶液中配伍后室温放置6h内的外观并测定pH,采用高效液相色谱(HPLC)法测定配伍液室温放置6h内夫西地酸的含量变化。结果与配伍0h比较,配伍液放置6h内的外观、色泽均无明显变化,pH略有变化;配伍液中夫西地酸含量无明显变化,均保持在95%以上,配伍6h内无新物质产生。结论夫西地酸与果糖在氯化钠溶液中配伍后室温放置6h内夫西地酸性质基本稳定。Objective To study the compatible stability of Fusidate Sodium for Injection in 0.9% Sodium Chloride Injection containing fructose sodium. Methods The content of the mixture in 0. 9% Sodium Chloride Injection were determined at different time by HPLC within 6 h; the appearance of the solution was observed and its pH was determined within 6 h. Results No significant differences were noted for the mixture in appearance, pH and contents within 6 h after mixing within 6 h. Conclusion The mixture of Fusidate Sodium for Injection in 0. 9% Sodium Chloride Injection containing fructose can be mixed to use within 6 h under the room temperature.

关 键 词：夫西地酸 果糖 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学] R978.1[医药卫生—药学]