湖北省儿童感染金黄色葡萄球菌4年耐药性分析  

Drug-resistance of Staphylococcus aureus in Children in Hubei During Four Years

作　　者：胡红兵[1] 夏维[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心,湖北武汉430016

出　　处：《中华医院感染学杂志》2009年第12期1582-1583,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解湖北省三级医院4年来儿童感染金黄色葡萄球菌(SAU)的耐药性变迁,为临床医师合理使用抗菌药物提供试验依据。方法回顾性调查2004-2007年湖北地区三级医院儿童感染的耐甲氧西林金黄色葡萄球菌(MR-SA)、甲氧西林敏感金黄色葡萄球菌(MSSA)临床株的药物敏感试验汇总资料,并对结果进行统计分析。结果4年来儿童感染MRSA呈逐年上升趋势(5.7%→10.7%→40.8%→46.9%);且MRSA对多种抗菌药物的耐药率均高于MSSA;未检出耐万古霉素金黄色葡萄球菌。结论湖北省SAU的耐药现象仍然十分严重,应采取有效措施,结合儿童的生理特点,合理使用抗菌药物,控制耐药菌的产生与暴发流行。OBJECTIVE To investigate the evolution of drug-resistance of Staphylococcus aureus in children in Hubei tertiary level hospitals during four years and provide the evidence for clinically reasonable use of antibiotics. METHODS The summary data of drug sensitivity in clinical isolates of meticillin-resistant S. aureus （MRSA） and meticillin-sensitive S. aureus （MSSA） in children in Hubei tertiary level hospitals from 2004 to 2007 were investigated retrospectively and the results were analyzed statistically. RESULTS The tendency of infections with MRSA upgraded yearly during four years（5.7%→10.7%→40.8%→46.9%）; the resistance rates of MRSA to various antibiotics were all higher than that of MSSA. The vancomycin-resistant S. aureus had not been detected. CONCLUSIONS The drug-resistance status of SA in Hubei is still very serious. We should adopt effective measurement to control the occurring and epidemic outbreak in combination with children physiological characteristic.

关 键 词：湖北省 三级医院 儿童组 金黄色葡萄球菌 甲氧西林 耐药性 

分 类 号：R378.11[医药卫生—病原生物学]