31例嗜麦芽寡养单胞菌性肺炎临床及药敏分析  

Stenotrophomonas maltophilia Pneumonia:An Analysis of Clinical Features and Antibiotic Susceptibility of 31 Cases

作　　者：龚燕[1] 

机构地区：[1]上海瑞金医院卢湾分院呼吸内科,上海200020

出　　处：《中华医院感染学杂志》2009年第12期1594-1595,共2页Chinese Journal of Nosocomiology

摘　　要：目的分析与总结嗜麦芽寡养单胞菌性肺炎的临床特点和对抗菌药物敏感性的分布情况。方法对31例嗜麦芽寡养单胞菌性肺炎患者的临床资料进行统计分析，以K～B法测定该菌的药物敏感性。结果31例中老年患者26例（83．87％），患有基础疾病患者31例（100．00％），院外感染10例（32．26％），院内感染21例（67．74％）；临床表现主要为咳嗽、咳痰31例（100．00％），发热17例（54．84％），呼吸困难24例（77．42％）；胸部X线均呈现程度不等肺部浸润阴影；药敏检测表明，除了对复方新诺明、环丙沙星、米诺环素、阿米卡星比较敏感外（71．43％～45．00％），该菌广泛耐药（28．57％～100．00％）。结论嗜麦芽寡养单胞菌肺炎好发于老年、有基础疾病、免疫功能低下者，及早选择可能敏感的抗菌药物及进行细菌药敏检测将改善预后。OBJECTIVE To analyze and summarize the clinical features and distribution of antibiotic susceptibility of Stenotrophomonas maltophilia pneumonia. METHODS We statistically analyzed the clinical data of thirty-one cases of S. maltophilia pneumonia,and determined drug susceptibility of this bacteriaum, using K-B methods. RESULTS Twenty-six out of 31（83.87 %） cases were old age patients. All Patients were with underlying diseases, while 17（54. 84%）cases had chronic obstructive pulmonary disease history and 15 （43. 39%） cases were with immunodeficiency. Out-of hospital infection and nosocomial infection were 10 （32.26 %） cases and 21 （67.74 %）, respectively. The clinical symptoms were mainly cough and expectoration （100. 00%）, 17 （54. 84%） cases had fever, and 24 cases（77. 42%） had dyspnea. Chest X-ray showed different-degree shadow on lungs. Besides compound sulfamethoxazole,ciprofloxacin, minocycline and amikacin were susceptive（71.41-45.00%）, the drug susceptibility test showed, that the microbe was resistant to lots of antibiotics（28.57-100.00 % ）. CONCLUSIONS The risk factors of S. maltophilia pneumonia are ageing, underlying diseases and immunodeficiency. Early choosing susceptive antibiotics and drug sensitivity test would improve the prognosis.

关 键 词：嗜麦芽寡养单胞菌 肺炎 药物敏感性 

分 类 号：R378[医药卫生—病原生物学]