感染性心内膜炎患者血培养病原菌及其耐药性分析  

Pathogens and Their Resistance in Infective Endocarditis Patients

作　　者：周碧蓉[1] 熊自忠[1] 李睿[1] 王中新[1] 

机构地区：[1]安徽医科大学第一附属医院心内科,安徽合肥230022

出　　处：《中华医院感染学杂志》2009年第12期1601-1602,共2页Chinese Journal of Nosocomiology

基　　金：安徽省优秀青年科技基金(08040106815)

摘　　要：目的了解安徽地区感染性心内膜炎的病原菌及其耐药性,为指导临床合理用药提供依据。方法对心内科收治的27例感染性心内膜炎患者的血培养菌株种类和药物敏感试验结果进行回顾性分析,病原菌的鉴定和药敏通过Mi-croScan WalkAway-40自动微生物鉴定和药敏分析系统进行测定。结果27株分离菌株中,酿脓链球菌占51.9%,葡萄球菌属占37.0%,其他细菌占10.1%;酿脓链球菌对四环素、红霉素的耐药率分别高达78.6%、42.9%;对氨苄西林的耐药率为14.3%、对青霉素、庆大霉素、氯霉素的耐药率为0;10株葡萄球菌属中,甲氧西林敏感葡萄球菌(MSS)6株,耐甲氧西林葡萄球菌(MRS)4株,MRS显示多药耐药,MSS的耐药率显著低于MRS;两种细菌对万古霉素的耐药率为0。结论感染性心内膜炎的病原菌以酿脓链球菌和葡萄球菌属为主,酿脓链球菌对四环素、红霉素耐药显著,对青霉素等较为敏感,MRS多药耐药,未发现万古霉素耐药株。OBJECTIVE To investigate pathogens and their resistance in infective endocarditis patients. METHODS Pathogens and their resistance were detected by MicroScan WalkAway-40 system. RESULTS Most of pathogens were Streptococcus pyogenes and Staphylococcus. The resistant rate of S. pyogenes to tetracycline, erythromycin, ampicillin, penicillin, gentamicin and chloramphenicol was 78.6%, 42.9%, 14.3%, 0, 0 and 0, respectively. Four were MRS in 10 Staphylococcus isolates and they were resistant to most antimicrohial agents except vancomycin and higher than MSS. CONCLUSIONS Most of pathogens are S. pyogenes and Staphylococcus in infective endocarditis patients; most S. pyogenes isolates are resistant to tetracycline, erythromycin, but susceptible to penicillins; MRS are resistant to most of antimicrobial agents except vancomycin.

关 键 词：感染性心内膜炎 酿脓链球菌 葡萄球菌属 耐药性 

分 类 号：R378[医药卫生—病原生物学]