通心贴对冠心病心绞痛患者血清M-CSF、HCY、GMP-140的影响  

Effects of Tongxin Plaster on Serum Macrophage Colony Stimulating Factor, Homocysteine and Granules Membrane Protein-140 in Patients with Coronary Heart Disease

作　　者：殷建明[1] 罗陆一[1] 张大创[1] 李根[1] 

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《中国中医药信息杂志》2009年第6期9-11,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：深圳市科技局课题(200405161)

摘　　要：目的观察通心贴对冠心病心绞痛肾阳亏虚兼痰瘀内阻证患者冠状动脉炎症、血小板活化作用的影响。方法将80例冠心病心绞痛肾阳亏虚兼痰瘀内阻证患者随机分为2组,治疗组41例,膻中、心俞二穴交替贴敷通心贴,每穴贴敷12h/次,1次/d,治疗3周;对照组39例,采用麝香保心丸口服,每次2粒(22.5mg/粒),3次/d,治疗3周。分别于治疗前后采集空腹静脉血,测定血清巨噬细胞集落刺激因子(M-CSF)、同型半胱氨酸(HCY)、血小板膜α颗粒膜蛋白-140(GMP-140)水平。结果2组治疗后血清M-CSF、HCY、GMP-140水平均明显降低(P<0.01),组间比较差异无统计学意义(P>0.05)。结论通心贴具有抑制冠状动脉炎症反应、抑制血小板活化、降低HCY水平的作用,这可能是其治疗冠心病心绞痛肾阳亏虚兼痰瘀内阻证的机理之一。Objective To study the effects of Tongxin Plaster on serum macrophage colony stimulating factor （M-CSF）, homocysteine （HCY）, and granules membrane protein-140 （GMP-140） of patients with angina pectoris of coronary heart disease. Methods Eighty CHD patients were randomly divided into two groups. Forty-one cases in treatment group were given acupoint application of Tongxin Plaster on acupoint Tanzhong （CV 17） and Xinshu （BL 15） 12 hours a day. Thirty-nine cases in control group were given orally Shexiangbaoxin Pill, 2 pills twice a day. The treatment course of the two groups was 3 weeks. The serum levels of M-CSF, HCY and GMP-140 were detected respectively. Results After treatment, the levels of M-CSF, HCY, GMP-140 in both groups were all decreased significantly （P〈0.01）. There was no significant difference in the levels of M-CSF, HCY, GMP-140 between the two groups （P〉0.05）. Conclusion Tongxin Plaster has good effects on antagonizing inflammatory response of coronary artery, inhibiting activation of platelets and degrading the level of homocysteine, which may be one of the mechanisms for Tongxin Plaster in treating CHD.

关 键 词：冠心病 心绞痛 通心贴 巨噬细胞集落刺激因子 同型半胱氨酸 血小板膜α颗粒膜蛋白-140 

分 类 号：R259.414[医药卫生—中西医结合]