耐甲氧西林金黄色葡萄球菌对抗菌药物MIC值的监测  

Surveillance on MIC of Antibiotic Resistance of Meticillin-resistant Staphylococcus aureus

作　　者：陈栎江[1] 周铁丽[1] 吴庆[1] 刘媚娜[1] 吴莲凤[1] 

机构地区：[1]温州医学院附属第一医院实验诊断中心,浙江温州325000

出　　处：《中华医院感染学杂志》2009年第11期1407-1409,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院5年分离的耐甲氧西林金黄色葡萄球菌(MRSA)对抗菌药物MIC值的变迁。方法用Etest法检测临床分离的MRSA对万古霉素、替考拉宁和利奈唑烷的MIC值。结果2003-2007年5年内,MRSA检出率从2003年的52.2%上升到2007年的74.5%,万古霉素的MIC几何均数从1.85μg/ml上升到2.15μg/ml,替考拉宁的MIC几何均数从1.28μg/ml上升到2.07μg/ml,利奈唑烷的MIC值的变化不大。结论2003-2007年5年内,MRSA检出率逐年上升,MRSA对万古霉素、替考拉宁的MIC值有升高的趋势,且以替考拉宁的升高更为明显。OBJECTIVE To review and analyze the change in the MICs of vancomycin, teicoplanin and linezolid in meticillin-resistant Staphylococcus aureus （MRSA） strains isolated in our hospital from 2003 to 2007. METHODS The MICs of vancomycin, teicoplanin and linezolid were tested by Etest method on a sample of randomly selected MRSA strains. RESULTS The incidences of MRSA increased from 52.2% in 2003 to 74.5% in 2007. MIC of vancomycin increased from 1. 85 μg/ml in 2003 to 2. 15 μg/ml in 2007, and teicoplanin MIC geometric mean increased even more markedly from 1.28 μg/ml in 2003 to 2.07 μg/ml in 2007. The linezolid MIC remained almost unchanged. CONCLUSIONS The incidences of MRSA were increasing from 2003 to 2007. There is a upward trend in MIC of glycopeptide over the years, in which the increase for teicoplanin is higher than others two.

关 键 词：耐甲氧西林金黄色葡萄球菌 万古霉素 替考拉宁 利奈唑烷 

分 类 号：R978.1[医药卫生—药品]