补肾化痰祛瘀类中药对PCOS模型大鼠生殖内分泌系统影响的实验研究  

Experimental Study on the Effect of Chinese Medicinals for Supplementing the Kidney,Dissolving the Phlegm and Removing the Blood Stasis on the Reproductive and Endocrine System of PCOS Model Rats

作　　者：邓阿黎[1] 周忠明[1] 张亚兵[2] 姜惠中[1] 金晶[1] 

机构地区：[1]湖北中医学院附属医院,湖北武汉430061 [2]武汉大学中南医院,湖北武汉430070

出　　处：《河南中医》2009年第6期551-554,共4页Henan Traditional Chinese Medicine

基　　金：湖北省武汉市科技局科技攻关项目(编号:20055102032-4)

摘　　要：目的:观察PCOS模型大鼠血清性激素T、FSH、LH及卵巢重量、面积的变化,探讨补肾化痰祛瘀类中药对PCOS模型大鼠生殖内分泌系统的影响。方法:用Poresky法诱导多囊卵巢综合征大鼠,并分别以补肾化痰祛瘀类中药、西药(罗格列酮)、中西药联合用药治疗,观察治疗后对血清性激素T、FSH、LH的影响以及卵巢重量和面积的变化。结果:补肾化痰祛瘀类中药能降低降低血清T、LH水平,以及降低LH/FSH比值,降低卵巢重量及卵巢平均面积。结论:补肾化痰祛瘀类中药能改善PCOS大鼠的生殖内分泌功能。Objective： To observe the changes of serum sex hormone T, FSH, LH and ovarian weight and area of PCOS model rats, and to probe the effect of Chinese medieinals for supplementing the kidney, dissolving the phlegm and removing the blood stasis on the reproductive and endocrine system of PCOS model rats. Methods： The model rats with polycystic ovarian syndrome were made with Poresky method and treated respectively with Chinese medieinals for supplementing the kidney, dissolving the phlegm and removing the blood stasis, Western medicine（rosiglitazone ） and the combined Western and Chinese medicine, and observed the changes of serum sex hormone T, FSH, LH and ovarian weight and area of PCOS model rats after the treatment. Resuits： Chinese medicinals for supplementing the kidney, dissolving the phlegm and removing the blood stasis roduced the level of T and LH and the ratio of LH and FSH, and decreased the ovarian weight and its average area. Conclusion： Chinese medicinals for supplementing the kidney, dissolving the phlegm and removing the blood stasis can improve the reproductive and endocrine function of PCOS model rats.

关 键 词：多囊卵巢综合征 补肾化痰祛瘀类中药 PCOS模型大鼠 生殖内分泌系统 

分 类 号：R285.5[医药卫生—中药学]