植入式铂－铱合金微电极的修饰和植入大鼠大脑运动皮层后的阻抗测量  

Modification of Implantable Pt-Ir Alloy Microelectrode and Impedance Monitoring in vivo

作　　者：刘炳辛[1] 鲁艺[1] 王定芳[1] 李涛[2] 周琴[2] 曹余良[1] 段晏文[1] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072 [2]武汉大学人民医院,湖北武汉430060

出　　处：《武汉大学学报（理学版）》2009年第3期253-257,共5页Journal of Wuhan University:Natural Science Edition

基　　金：国家高技术研究发展计划(863)项目(2006AA02Z4E6);国家自然科学基金资助项目(30570516)

摘　　要：植入电极是植入电刺激器的一个重要部件,为了降低植入电极的阻抗和减少组织的炎性反应,本文针对植入电极界面的特性要求,采用逐层修饰的方法,先用电化学方法在铂-铱合金微电极(d=75μm)上沉积氧化铱,然后在绝缘封装材料硅橡胶上接枝一层高分子涂层聚乙烯醇/聚丙烯酸(PVA/PAA).经修饰的微电极植入大鼠大脑运动皮层运动区一个月,在第21天测量其电极阻抗.结果初步显示逐层修饰的电极阻抗降低了53%.行为学评价显示电极在植入大鼠运动皮层后没有对大鼠的运动行为产生不良影响.The implanted electrode is one of the key elements in implantable neural stimulators. One challenge is to reduce the electrode impedance and minimize tissue inflammatory response. Based on the requirements of interface characteristics, the study investigated a layer-by-layer modification approach. The electrodes （d= 75 μm） made from Platinum-Iridium （Pt-Ir） alloy wire were electrochemically modified with iridium oxides, and then a thin coating of poly（vinyl alcohol）/poly（acrylic acid） （PVA/PAA） was grafted onto the silicone rubber serving as the insulating and supportive material for the electrodes. These electrodes were implanted into the motor area of a rat＇s cortex for a month. The electrode impedance was measured on the 21st day after implantation. The results show that the electrode impedance is reduced by 53% compared with the impedance of non-modified electrodes. The chronic experiment in vivo does not cause adverse effects, as suggested by behavioral assessment experiments.

关 键 词：电极-神经界面 生物相容性涂层 植入电极修饰 植入电极阻抗 神经假体 

分 类 号：O646[理学—物理化学]