层层组装构建抗凝血和内皮细胞化协同功能界面  

Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification

作　　者：林全愧[1] 阎嘉洁[1] 计剑[1] 沈家骢[1] 

机构地区：[1]浙江大学高分子科学与工程学系,教育部高分子合成与功能构造重点实验室,杭州310027

出　　处：《高等学校化学学报》2009年第6期1256-1258,共3页Chemical Journal of Chinese Universities

基　　金：国家“八六三”计划(批准号:2006AA03Z329);国家“九七三”计划(批准号:2005CB623902);浙江省科技计划(批准号:2007C24008);吉林大学超分子结构与材料国家重点实验室开放课题基金(批准号:SKLSSM200712)资助

摘　　要：Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation.In this research,a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition.The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated multilayer took on excellent hemocompatibility.The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification.Such multilayered endovascular stents with excellent hemocompatibilty and human endothelial cytocompatibility may have great potential in clinical applications.Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation. In this research, a polyeleetrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition. The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated muhilayer took on excellent hemocompatibility. The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification. Such multilayered endovascular stents with excellent hemocompatibihy and human endothelial cytocompatibility may have great potential in clinical applications.

关 键 词：层层组装 细胞外基质 抗凝血 细胞相容性 

分 类 号：O631[理学—高分子化学]