心脏不停跳二尖瓣置换术血浆降钙素基因相关肽变化研究  

Changes of Calcitonin Gene-related Peptide with Suffer Hypothermic Replacement of Mitral Valve in Beating Heart

作　　者：冼磊[1] 陈铭伍[1] 冯旭[1] 何巍[1] 周华富[1] 覃家锦[1] 

机构地区：[1]广西医科大学第一附属医院心胸外科,南宁市530021

出　　处：《广西医学》2009年第5期612-613,共2页Guangxi Medical Journal

基　　金：广西教育厅科研基金

摘　　要：目的探讨不同温度心脏不停跳二尖瓣置换术对心肌保护效果。方法将60例风湿性心脏病二尖瓣病变的患者随机分为实验组(中度低温心不停跳组)与对照组(浅低温心脏不心停跳组),每组30例,于6个时点采静脉血,检测血浆降钙素基因相关肽(CGRP)。结果两组转机后CGRP持续升高,对照组较实验组升高更明显(P<0.05)。结论浅低温心脏不停跳二尖瓣置换术较中度低温有利于CGRP的合成及释放,可能具有较好的心肌保护效果。Objective To discuss the myocardial protective effects in different temperature in beating heart. Methods Sixty patients underwent rheumatic heart disease united cardio valve replacement were randomly divided into experiment group （beating heart in moderate hypothennia,n = 30） and control group （beating heart in mild hypothermia, n = 30）. Plasma calcitunin gene-related peptide （CGRP） of two groups were respectively measured and contrasted at six different time intervals. Results CGRP in two groups continuously increased in varying degree during CPB,CGRP in control group increased more quickly than in experiment group （P 〈 0. 05）. Conclusion The composition and release of CGRP reduced in beating heart united cardio valve replacement in mild hypothennia than in moderate hypothermia,it might be mere efficient in myocardial protection.

关 键 词：中度低温 心脏不停跳术 二尖瓣置换术 降钙素基因相关肽 心肌保护 

分 类 号：R654.2[医药卫生—外科学]