CRF、IL-10在慢性阻塞性肺疾病急性加重期的作用研究  

Study of Function of CRF、IL-10 in Acute Exacerbation of COPD

作　　者：李建华 王永志 林勇[2] 

机构地区：[1]山东省兖矿集团南屯矿医院,邹城市273515 [2]山东省济宁市第一人民医院,济宁市272000

出　　处：《医药论坛杂志》2009年第10期1-3,共3页Journal of Medical Forum

摘　　要：目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者治疗前后血IL-10、CRP等炎症因子的浓度变化及其与肺功能损害的相关性。方法采用ELISA分析30例AECOPD患者治疗前后血清IL-10、C-反应蛋白,测PaO2、FEV1、FEV1/FVC%、外周血白细胞计数和中性粒细胞百分比,分析IL-10、CRP与FEV1和FEV1/FVC%的相关性。结果在AECOPD患者中,治疗前后IL-10浓度分别为(176.5±71.0)pg/L和(219.9±105.2)pg/L,比对照组(359.3±156.1)pg/L低;治疗前后CRP浓度分别为(23.9±17.8)mg/L和(10.1±4.2)mg/L,均比对照组(6.7±1.8)mg/L高;差异均有统计学意义。IL-10浓度与FEV l%、FEV l/FVC变化呈正相关(P<0.05);CRP浓度与FEV l%、FEV1/FVC呈负相关(P<0.05)。结论AECOPD患者血IL-10浓度较对照组低,而CRP浓度较对照组高;血IL-10和CRP的浓度与肺功能损害程度相关。Objective To investigate the changes of Interleukin- 10（IL- 10）, and C -reactive protein（CRP）levels in patients with acute exacerbation of chronic obstructive pulmonary diseases（AECOPD） and to analyze the correlation between the inflammatory factor and COPD. Methods The levels of IL - 10 and CRP in thirty cases of patients with AECOPD were measured by enzyme - linked immunosorheot assay. The amounts of neutmphils, PaO2 and lung function indexes such as the forced expiratory volume in one second（FEV1） and the forced expiratory volume in one second/forced vital capacity（FEV1/FVC） were also determined. Results From the time of beginning therapy to the time of after - therapy,the AECOPD patients showed a significant decrease in IL - 10[ （ 176. 5 ± 71.0） pg/L, （219.9 ±105.2） pg/L respectively） vs（359.3 ±156. 1 ） pg/L] ,but showed a notable increase in CRP[ （23.9 ± 17.8 ） mg/L, （ 10. 1± 4.2） mg/L respectivdy） vs （6.7 ± 1.8 ） mg/L ]. serum IL - 10 concentrations with FEV1% （ P 〈 0. 05 ） and FEV 1/FVC （ P 〈 0. 05 ） were positively correlated, while CRP with FEVI% （ P 〈 0. 05 ） and FEVUFVC （P 〈 0.05 ） were negatively correlated. Conclusion The serum IL- 10 levels in the patients with AECOPD is lower than that of the healthy control group,＇ While IL - 10 and CRP levels are higher than that of the healthy control group. The damage of lung function in patients with AECOPD is associated with the serum levels of IL - 10 and CRP.

关 键 词：慢性阻塞性肺疾病 白细胞介素-10 C-反应蛋白 

分 类 号：R563[医药卫生—呼吸系统]