辛伐他汀对2型糖尿病患者凝血及血管内皮炎性的影响  

Anti-Inflammatory and Anticoagulant Effects of Simvastatin in Patients with noninsulin-dependent diabetes mellitus

作　　者：李凤芹[1] 熊辉[2] 刘健群[1] 

机构地区：[1]北京市丰台医院,100071 [2]北京大学第一医院急诊科

出　　处：《中国实用医药》2009年第16期9-10,共2页China Practical Medicine

摘　　要：目的探讨他汀类药物对2型糖尿病(NIDDM)患者凝血功能及血管内皮炎性的影响。方法113例NIDDM患者,其中观察组53例口服辛伐他汀合并阿司匹林。对照组60例仅口服阿司匹林。分别对两组在服用辛伐他汀8周前后采血检测空腹血糖(FPG)、血浆纤维蛋白原(Fg)、D-二聚体(D-di-mer),C-反应蛋白(CRP)、甘油三酯(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL)和低密度脂蛋白胆固醇(LDL)。结果观察组服用辛伐他汀8周后TC,TG,LDL和CRP较服药前均明显降低(P<0.05)。Fg和D-dimer服药前后无显著性差异(P>0.05)。结论他汀类药物能明显改善糖尿病患者血脂胆固醇水平及血管内皮炎性反应,对防治并发症具有临床指导意义。Objective To study the anti-inflammatory and anticoagulant effects of simvastatin in patients with noninsulin-dependent diabetes mellitus （NIDDM）. Methods 113 patients were divided into two groups. 53 patients in study group were designed with an 8-week intervention period with simvastatin and aspirin. 60 patients in control groups had no intervention as normal with aspirin. We evaluated fasting plasma glucose, plasma fibrinogcn level, D-dimer, and C-reactive protein （CRP） triglyceride（TG）, total, high density lipoprotein （ HDL）, and low density lipoprotein （LDL） cholesterol in blood samples drawn after fasting on day 0 and after 8 weeks. Results Significant reductions of total cholesterol （ P 〈 0. 01 ）, LDL cholesterol （ P 〈 0. 05 ）, triglycerides （ P 〈 0. 05 ） and CRP （P 〈 0. 05 ） were achieved after 8 weeks of treatment with simvastatin. Levels of fibrinogcn and D-dimer did not decrease after treatment with simvastatin （ P 〉 0. 05）. Conclusion The results indicated that simvastatin reduces levels of TC , TG and inflammation markers in type 2 diabetic patients. These effects of treatment with statins could play a role in reducing vascular complications in patients with NIDDM.

关 键 词：2型糖尿病(NIDDM) 他汀类 C-反应蛋白(CRP) 甘油三酯(TG) 总胆固醇(TC) 纤维 蛋白原(Fg) D-二聚体(D-dimer) 

分 类 号：R587.1[医药卫生—内分泌] R972.6[医药卫生—内科学]