莱姆关节炎发病机理研究进展  

Advances in pathogenesis of Lyme arthritis

作　　者：宝福凯[1] 柳爱华[2] 马海滨[3] 吴娜 

机构地区：[1]昆明医学院微生物学与免疫学教研室,云南昆明650031 [2]昆明医学院生物化学与分子生物学教研室,云南昆明650031 [3]云南省地方病防治所,云南大理671000 [4]云南省峨山县医院内科,云南峨山653200

出　　处：《中国病原生物学杂志》2009年第5期380-382,386,共4页Journal of Pathogen Biology

基　　金：云南省自然科学基金项目(No.2007C069M)。

摘　　要：莱姆病是一种虫媒传染病,其病原体是伯氏疏螺旋体。莱姆病主要表现为皮肤游走性红斑、复发性关节炎、心脏传导障碍和神经系统损害。其中,莱姆关节炎发生率和致残率高,危害最大。莱姆关节炎的发病机制尚不完全清楚,主要原因可能是螺旋体脂蛋白在感染早期引起机体固有免疫应答,随后引起适应性免疫应答,从而造成关节的炎症和损伤。本文对近年有关莱姆关节炎的研究进展进行简要总结,并介绍了作者在莱姆关节炎研究中的一些重要发现。Lyme disease is an arthropod-borne infectious disease, whose hallmarks are erythema migrans （EM）, episodes of arthritis, disruption of electrical conduction of cardiac muscle, and the development of neurological abnormalities. Some of these clinical features, especially arthritis, subside and recur throughout the course of infection. Arthritis is a leading cause of Lyme disease-associated morbidity, affecting approximately 60% of individuals infected with B. burg-dorferi. Intermittent episodes of arthritis develop several weeks or months after infection. The highly inflammatory aspects of Lyme arthritis can lead to cartilage and bone erosion with permanent joint dysfunction. The mechanism（s） by which B. burgdorferi interacts with the host immune system to induce arthritis is not fully understood. Initially, effectors of the innate immune system play a significant role in the induction of Lyme arthritis. Afterwards, a variety of host mechanisms work together to initiate an adaptive immune response to the organisms and induce a strong inflammation process in the joints. A synopsis of data from studies of Borrelia-infected humans and animals of currently known mechanisms responsible for the induction of Lyme arthritis following infection with B. burgdorferi was introduced.

关 键 词：莱姆病 伯氏疏螺旋体 莱姆关节炎 综述 

分 类 号：R514[医药卫生—内科学]