间尼索地平的胶束电动毛细管电泳法测定  

Determination of m-Nisoldipine by Micellar Electrokinetic Capillary Chromatography

作　　者：孔德志[1] 张兰桐[1] 段坤峰[1] 崔洋[1] 杨维[1] 

机构地区：[1]河北医科大学药学院药物分析教研室,河北石家庄050017

出　　处：《中国医药工业杂志》2009年第6期450-451,456,共3页Chinese Journal of Pharmaceuticals

基　　金：河北省自然基金资助项目(C2008001073)

摘　　要：建立了胶束电动毛细管电泳法测定间尼索地平。采用未涂层融硅石英毛细管,10mmol/L磷酸二氢钠-5mmol/L硼砂缓冲液(含30mmol/LSDS,pH8.1)为运行缓冲液,分离电压30kV,检测波长214nm。间尼索地平浓度在30～120μg/ml范围内线性关系良好,检测限为0.9μg/ml。A micellar electrokinetic capillary chromatographic method was established for the determination of m-nisoldipine. An uncoated fused silica capillary column was used, with running buffer of 10 mmol/L sodium dihydrogen phosphate-5 mmol/L borax buffer （containing 30 mmol/L SDS, pH 8.1）, at the applied voltage of 30 kV and the detection wavelength of 214 nm. The calibration curve for m-nisoldipine was linear in the concentration range of 30 - 120 μg/ml with the detection limit of 0.9 μg/ml.

关 键 词：间尼索地平 胶束电动毛细管电泳 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.8[化学工程—制药化工]