Effects of ciclosporin on whole blood chemiluminescence of renal transplant patients  

作　　者：陈树元[1] 刘世霆[1] 侯连兵[1] 陈志良[1] 

机构地区：[1]第一军医大学南方医院临床药理室

出　　处：《中国药理学报》1998年第4期372-375,共4页Acta Pharmacologica Sinica

摘　　要：ｆｅｃｔｓｏｆｃｉｃｌｏｓｐｏｒｉｎｏｎｗｈｏｌｅｂｌｏｏｄｃｈｅｍｉｌｕｍｉｎｅｓｃｅｎｃｅｏｆｒｅｎａｌｔｒａｎｓｐｌａｎｔｐａｔｉｅｎｔｓＣＨＥＮＳｈｕＹｕａｎ１，ＬＩＵＳｈｉＴｉｎｇ，ＨＯＵＬｉａｎＢｉｎｇ，ＣＨＥＮＺｈｉＬｉａｎｇｇ...AIM: To examine the possible inhibitory role of ciclosporin (Cic) on luminol dependent chemiluminescence (CL) of whole blood in renal transplant patients. METHODS: Luminol dependent CL was used to measure active oxygen species generation in respiratory burst of whole blood stimulated by zymosan A. Fluorescence polarization immunoassay was used to monitor the blood concentration of Cic. RESULTS: CL values of Cic group ( n =50) decreased in comparison with those of normal group ( n =10) ( P <0 01). The blood concentration of Cic was negatively related to CL value ( P <0 01). The serum of renal transplant patients directly inhibited respiratory burst of peritoneal macrophages of rats in a concentration dependent manner. CONCLUSION: Cic inhibits the phagocytic activity of neutrophils in renal transplant patients.

关 键 词：肾移植 化学发光 环孢素 嗜中性白细胞 

分 类 号：R699.2[医药卫生—泌尿科学] R979.5[医药卫生—外科学]