α_1受体阻滞剂在ESWL治疗输尿管下段结石中的应用  

Role of alpha-adrenergic blockers in management of lower ureteral calculi with extracorporeal shock wave lithotripsy

作　　者：钱声华[1] 孙小春[1] 沈云奎 

机构地区：[1]吴江市第二人民医院泌尿外科,江苏吴江215221

出　　处：《临床和实验医学杂志》2009年第6期69-70,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的评价α1受体阻滞剂坦索罗辛在体外冲击波碎石(ESWL)治疗输尿管下段结石中的辅助排石效果。方法将符合条件的60例输尿管下段结石的患者行ESWL治疗后随机分成两组,一组给予常规治疗作为对照,另一组除给予常规治疗外增加坦索罗辛0.4mg/d,观察时间为2周。结果在观察时间内对照组排石率(63.3%)明显低于治疗组(86.7%),对照组肾绞痛发生率(26.7%)明显高于治疗组(6.7%),两组比较两个结果差异均有统计学意义(P<0.05)。结论坦索罗辛能提高输尿管下段结石ESWL后的排石率,减少肾绞痛的发生几率,可作为输尿管下段结石ESWL后的辅助排石治疗。Objective To evaluate the efficacy of alpha - 1 receptor blocker （tamsulosin） in management of lower ureteral calculi with extracorporeal shock wave lithotripsy （ESWL）. Methods A total of 60 patients with symptomatic lower ureteral calculi were randomly divided into 2 groups. After ESWL, patients in group I received standard medical therapy alone （controls）. Patients in group I1 received alpha - 1 receptor blocker （ tamsulosin 0.4 mg daily） for 2 weeks. Results During the observation period, the rate for excretion of calculi in control group （ 63. 3% ） was significantly lower than that of treatment group（ 86.7% ）. The incidence of renal colic was significantly higher in control group （ 26. 7% ） than that of treatment group （6.7%）. There was statistically significant difference between results of beth groups. Conclusion The results of this study have demonstrated that tamsulosin is effective as an adjunctive drug for treatment of patients with lower ureteral calculi after ESWL.

关 键 词：输尿管下段结石 体外冲击波碎石 坦索罗辛 

分 类 号：R693.4[医药卫生—泌尿科学] R972.4[医药卫生—外科学]