随机限食对小鼠代谢产热的影响  

Effect of the Random Restricting Food on the Energy Metabolism and Thermogenesis in KM Mice

作　　者：赵志军[1,2] 曹静[1] 田野[1] 王瑞瑞[1] 王桂英[1] 

机构地区：[1]聊城大学农学院,山东聊城252059 [2]山东省生态学与生物多样性重点实验室,山东聊城252059

出　　处：《安徽农业科学》2009年第16期7460-7461,7497,共3页Journal of Anhui Agricultural Sciences

基　　金：国家自然基金资助项目(30800130);聊城大学博士科研启动基金资助项目(31805)

摘　　要：[目的]研究随机限食条件下KM小鼠的代谢产热,深入理解能量代谢和产热在动物适应限食应激中的作用和意义。[方法]成年KM小鼠随机限食4 d周/,共驯化4周,采用封闭式流体压力呼吸计测定基础代谢(BMR)和非颤抖性产热(NST)。[结果]对照组动物体重增长了15.1%,而限食组降低了5.3%,限食组显著低于对照组(P<0.01);随机限制显著增加了摄食量,摄食量最大值为(11.94±0.52)g/d,比对照组高132.8%(P<0.001);限食使BMR(P<0.05)和NST(P<0.05)显著降低;随机限食使胴体重显著降低(P<0.01),但未影响脂肪重量和含量(P>0.05)。[结论]动物能通过能量摄入和支出的权衡策略适应随机限食的应激环境,代谢和产热的适应性调节在能量代谢的权衡策略中发挥重要作用。[ Objective ] The role and significance of the reaction of the animal restricted in food to energy metabolism and thermogenesis were fully understood through the research on the random restricting food of KM mice. [ Method] The diet for the adult male KM mice were restricted for 4 days/week in successive weeks and and the basal metabolic rate（BMR） and non-shivering thermogenesis（NST） of the treated mice were measured with a closed-circuit respirometer. [ Results] The body weight of the Ck was increased for 15.1% and the Treatment, was reduced for 5.3% , which was significant difference. The food-taking of mice was significantly raised after treatment with the maximum amount of food-taking was （11.94 ± 0.52）g/day and the BMR and NST in treatment group were reduced（ P 〈 0.05 ） and the body weight of the treated mice was＂ significantly decreased（ P 〈 0.01 ）, which did not affect the content of fat. [ Conclusion ] Animal could balance his metabolism under the stress and the physiological regulations of animal played important role in energy metabolism and thermogenesis under random food restricting stress.

关 键 词：限食 代谢 产热 小鼠 

分 类 号：Q494[生物学—生理学]