Guillain-Barrésyndrome following hepatitis E  

作　　者：Jean Philippe Loly Estelle Rikir Maxime Seivert Emile Legros Pierre Defrance Jacques Belaiche Gustave Moonen Jean Delwaide 

机构地区：[1]Department of Hepato-Gastroenterology,CHU Sart Tilman,Universitéde Liège [2]Department of Neurology,CHU Sart Tilman,Universitéde Liège [3]General Practitioner [4]Department of Hepato-Gastroenterology,CHPLT La Tourelle

出　　处：《World Journal of Gastroenterology》2009年第13期1645-1647,共3页世界胃肠病学杂志（英文版）

摘　　要：Guillain-Barrésyndrome(GBS)is often triggered by a preceding bacterial or viral infection.Occasionally,it has been observed in association with acute hepatitis A,B and C,and three cases have been previously described in India in which GBS was associated with acute hepatitis E.A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents,although the nature of the shared epitopes has not been characterized in most instances,including that in the case of hepatotropic viruses.We report a case of GBS following acute hepatitis E in a European individual.The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.Guillain-Barré syndrome （GBS） is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.

关 键 词：GANGLIOSIDES Guillain-Barré syndrome Hepatitis E Molecular mimicry Viral hepatitis 

分 类 号：R512.6[医药卫生—内科学]