晚期氧化蛋白产物与慢性肾脏病Ⅴ期非透析患者心血管疾病的关系  

Relationship between Advanced Oxidation Protein Products and Cardiovascular Diseases in Nondialysis Patients with Stage Ⅴ Chronic Kidney Disease

作　　者：田洁[1] 夏天[2] 魏肃[1] 王冰月[1] 赵继红[1] 

机构地区：[1]天津医科大学三中心临床学院肾内科,300170 [2]天津医科大学第二医院肾内科

出　　处：《天津医药》2009年第6期449-452,共4页Tianjin Medical Journal

摘　　要：目的:观察慢性肾脏病Ⅴ期(CKDⅤ期)非透析患者血浆晚期氧化蛋白产物(AOPPs)水平,并探讨AOPPs与CKD患者心血管疾病(CVD)的关系。方法:对50例CKDⅤ期非透析患者(CKD组)及31例健康志愿者(对照组)进行血浆AOPPs测定。CKD组同时检测血生化指标,并使用彩色多普勒超声诊断仪检测颈动脉粥样硬化相关指标及左心室肥厚相关指标。分析AOPPs与颈动脉粥样硬化、左心室肥厚及既往CVD病史的关系。结果:CKD组血浆AOPPs水平明显高于对照组(P<0.01)。血浆AOPPs水平与颈总动脉IMT(r=0.593,P<0.01)及LVM(Ir=0.355,P<0.05)呈正相关。多元逐步回归分析,AOPPs是颈总动脉IMT(β=0.574,P<0.01)及LVM(Iβ=0.336,P<0.05)的显著相关因素。既往有CVD史的患者血浆AOPPs水平显著高于既往无CVD的患者(P<0.05)。结论:CKDⅤ期非透析患者普遍存在高AOPPs血症,AOPPs可能参与慢性肾脏病Ⅴ期非透析患者CVD的发生和发展。Objective：To investigate the relationship between plasma advanced oxidation protein products （AOPPs） and cardiovascular disease （CVD） in nondialysis patients with stage V chronic kidney disease （CKD）. Methods：Fifty patients with stage V CKD and 31 healthy controls were enrolled in this study. Plasma levels of AOPPs were tested in both groups. Biochemical indexes were tested in observed group. Color-coded duplex sonography was used to determine the carotid atherosclerosis and left ventricular hypertrophy （LVH） indexes. The correlations between AOPPs and CVD were analyzed. Results：The serum AOPPs level was obviously higher in the observed group than that of control group （P 〈 0.01）. Plasma AOPPs level was positively correlated with common carotid artery IMT（r = 0.593 ,P 〈 0.01 ）and LVMI（r = 0.355 ,P 〈 0.05）. Multiple linear stepwise regression analysis showed that AOPPs were obvious correlation factors to common carotid artery IMT （β=0.574 ,P 〈 0.01） and LVMI （β = 0.336,P 〈 0.05）. Those patients who had previous CVD had obviously higher serum AOPPs [（22.29±9.20）vs （16.89±3.40） μmol/L,P 〈 0.05]. Conclusion ：The nondialysis patients with stage V CKD had higher AOPPs levels. AOPPs may be involved in the occurrence and progress of CVD in nondialysis patients with stage V CKD.

关 键 词：蛋白水解产物 慢性病 肾疾病 心血管疾病 回归分析 

分 类 号：R692[医药卫生—泌尿科学] R692.5[医药卫生—外科学]