代谢综合征与2型糖尿病肾病、视网膜病的相关性分析  

The Association Analysis between Metabolic Syndrome and Diabetic Nephropathy and Diabetic Retinopathy

作　　者：王利霞[1] 赵伟[1] 张宏[1] 朱艳娟[1] 李美[1] 闫雪[1] 王玲[1] 

机构地区：[1]天津医科大学代谢病医院,卫生部及天津市激素与发育重点实验室,300070

出　　处：《天津医药》2009年第6期456-458,共3页Tianjin Medical Journal

摘　　要：目的:探讨代谢综合征(MS)与2型糖尿病肾病(DN)、视网膜病(DR)的相关性。方法:分析334例2型糖尿病患者的住院资料,根据有无代谢综合征分为合并代谢综合征组(MS组)和非代谢综合征组(非MS组),比较两组DN、DR的患病率,并分析DN、DR与MS主要组分、MS的相关性。结果:MS组的DN、DR的患病率分别为28.70%、39.13%,高于非MS组的9.62%和27.88%(P<0.05);DN与年龄、可追溯糖尿病病程、吸烟、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c)和三酰甘油(TG)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关,DR与年龄、可追溯糖尿病病程、SBP、DBP、HbA1c呈正相关;在调整了性别、年龄、可追溯糖尿病病程、吸烟、HbA1c后,MS与DN、DR仍相关(OR分别为4.281、1.889;95%CI分别为2.064～8.879、1.091～3.270)。结论:MS与DN、DR的患病率密切相关,有效地改善代谢综合征可能对糖尿病微血管并发症的防治有重要临床意义。Objective： To investigate the association between metabolic syndrome and diabetic nephropathy and diabetic retinopathy. Methods： The clinic documents of 334 patients with type 2 diabetes were divided into two groups based on with/ without metabolic syndrome. The prevalence of diabetic nephropathy and diabetic retinopathy was compared in two groups. The associations between diabetic nephropathy and diabetic retinopathy and the major components of metabolic syndrome were analyzed. Results： The patients with the metabolic syndrome had a higher prevalence of diabetic nephropathy and retinopathy than that in patients without the syndrome （P〈 0.05）. The nephropathy had a positive correlation with age, ascend duration of diabetes, smoking, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, glycosylated HbA1c and TG. Using univariate analysis it was also found that the nephropathy had a negative correlation with HDL-C. The retinopathy was associated with age, ascend duration of diabetes, SBP, DBP and glycosylated HbA1c. In a multiple logistic regression analysis, after adjusting the gender, age, the ascend duration of diabetes, smoking and glycosylated HbA1c, the metabolic syndrome had a predominant relation with diabetic nephropathy and retinopathy （OR= 4.281,1.889;95%CI： 2.064-8.879,1.091- 3.270）. Conclusion： The metabolic syndrome is closely associated with the prevalence of diabetic nephropathy and retinopathy. There will be a clinical significance in preventing and treating diabetic microvascular complications by improving metabolic syndrome.

关 键 词：代谢综合征X 糖尿病 2型 糖尿病肾病 糖尿病视网膜病变 LOGISTIC模型 

分 类 号：R587.2[医药卫生—内分泌] R589[医药卫生—内科学]