彩超观察绝经后妇女长期应用激素补充疗法后血管内皮功能改变  

Study on endothelium function in post-menopause women with long duration hormone replacement treatment by color Dopplor ultrosonography

作　　者：范存芳[1] 

机构地区：[1]山东省荣军总医院特检科,山东济南250013

出　　处：《医学影像学杂志》2009年第5期599-601,共3页Journal of Medical Imaging

摘　　要：目的:应用高分辨率彩色多普勒超声观察绝经后妇女长期应用激素补充疗法(HRT)后血管内皮功能的改变。方法:对40例绝经后妇女长期应用激素补充疗法(HRT)后,观察其反应性充血时和舌下含服硝酸甘油后肱动脉内径的变化,并与对照组进行比较。结果:绝经后妇女长期应用激素补充疗法(HRT)后反应性充血时肱动脉内径的扩张程度(15.45±5.91)与对照组(11.56±5.46)相比在统计学上有显著性差异(P<0.01)。舌下含服硝酸甘油后肱动脉内径的变化两组间有显著性差异(P<0.01)。结论:绝经后妇女长期应用激素补充疗法(HRT)后,其血管内皮依赖性及非依赖性舒张功能得到改善,从而发挥雌激素对绝经后妇女心血管的保护作用,降低绝经后妇女心血管疾病的发病率。Objective：To study the impact of long period HRT on endothelium function in post-menopause women with high resolution color Doppler uhrasonography technique.Methods： After long duration of HRT for 1.5 year, the inside diameter of humeral artery in 40 post-menopause women was determined with high resolution Doppler ultrasonography technique, with responsive congestion or with sublingual dosage of nitroglycerin, and the data was compared with normal control. Results：After HRT, the inner diameter of humeral artery （IDHA） in experimental group with responsive congestion was 15.45 ± 5.91, with statistical difference compared to 11.56 ± 5.46 in control group （ P 〈 0.05）; while the IDHA in HRT group with nitroglycerin stimulus was 17.41 ± 5.17, compared with 13.31 ± 5.07 in control group, also with statistical difference （P 〈 0.05）. Conclusion： After HRT, both endothelium dependent and independent relaxation function are ameliorated, and the risk is reduced for cardiovascular disease attack among post-menopause women due to the protection effects of estrogen hormone on cardiovascular system.

关 键 词：绝经后妇女 激素补充疗法 血管内皮功能 彩色多普勒超声 

分 类 号：R713.5[医药卫生—妇产科学] R445.1[医药卫生—临床医学]