放射性碘致大鼠甲状腺损伤的形态计量学研究  

Morphometric study of 131I induced injury in rat thyroid.\

作　　者：安艳[1,2] 陈如松[1,2] 涂开成[1,2] 曹珍山[1,2] 郭丰莉 李茂河[1,2] 

机构地区：[1]中国辐射防护研究院 [2]北京放射医学研究所

出　　处：《中华放射医学与防护杂志》1998年第3期159-163,共5页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的为了定量测定１３１Ｉ照射后大鼠甲状腺的有关组织学参数变化。方法通过计算机图像分析系统，采用体视学方法，从大鼠甲状腺的腺体水平和细胞水平测定了各项形态计量学参数（包括二维和三维）。结果所测得的一些形态计量学参数随甲状腺剂量改变而增加或减少。结论尽管在较低剂量１３１Ｉ照射下，与对照组相比，大鼠生长发育和甲状腺功能未出现明显的差异，但所测的各项参数与甲状腺吸收剂量之间呈现较好的剂量效应关系，其中尤以胶体体积密度参数的变化最为明显，其Ｄ２５值和Ｄ５０值为最低。Objectives\ To quantitatively measure the morphometric parameters of the strutural changes in rat thyroid irradiated with 131I.Methods \ By using a computerized image analysis system and the stereological method,some morphometric parameters at glandular and cellular levels including two and three dimensions can be measured successfully.Results \ Some morphometric parameters were gradually decreased or increased with the increase of 131I dose level.Conclusions\ Compared with the control group,even though there was no obvious changes in growth and function of the thyroid irradiated with low level　131I,the response of morphometric parameters was in good relationship with dose.Among the parameters,the volume density of colloid(Vvc) changed obviously and the values of D25 and D50 were the lowest.

关 键 词：放射性碘 碘 吸收剂量 形态计量学 甲状腺损伤 

分 类 号：R818.81[医药卫生—放射医学] R144.1[医药卫生—临床医学]