梭曼和乙基梭曼离体透皮吸收的研究  

The comparative study of percutaneous absorption of soman vs ethyl soman

作　　者：刘星[1] 耿建兵[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《军事医学科学院院刊》1998年第1期5-7,共3页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的：比较密闭和开放不同条件下梭曼和乙基梭曼透皮吸收的特点。方法：采用动式离体皮渗透装置，接收液中梭曼或乙基梭曼的浓度采用微量电鳐乙酰胆碱酯酶抑制法测定。结果：梭曼或乙基梭曼皮肤染毒后，经过约１５ｍｉｎ的延搁期后经皮渗透量逐渐增加，至２～３ｈ达高峰，之后逐渐下降。无论是开放或密闭条件染毒，乙基梭曼经皮渗透量均比梭曼多。毒剂皮肤染毒后９ｈ，开放条件下，乙基梭曼经皮渗透量是梭曼的７．２倍；密闭条件下，乙基梭曼经皮渗透量是梭曼的４．１倍。结论：乙基梭曼透皮毒性比梭曼大的主要原因在于其经皮渗透能力较强。Objective: To compare percutaneous absorption of soman vs ethyl soman with an open or close method of skin contamination. Methods: A perfusing glass diffusion cell system was used for the study. Concentrations of soman or ethyl soman in the perfusion fluid were measured by microassay of eel AChE inhibition . Results:Results of the study showed that the amount of soman or ethyl soman permeating through skin gradually increased after about 15 minutes of delay, reached the peak 2-3 hours later, and then dropped.The amount of ethyl soman permeating through skin was 7.2 times as much as that of soman within the experimental time in open type of skin contamination; and 4.1 times as much as that of soman in a closed type of skin contamination. Conclusion: The permeability of ethyl soman through skin is higher than that of soman.This may be the cause of stronger skin toxicity for ethyl soman.

关 键 词：梭曼 乙基梭曼 透皮吸收 毒理学 离体皮渗透装置 

分 类 号：R827.172[医药卫生—临床医学]