模拟失重大鼠骨质内细胞因子变化与骨代偿性调节  

Changes of Bone Cytokines and Compensating Regulation in tail Suspended Rats.

作　　者：崔伟[1] 阚广捍[1] 谢力勤[1] 刘成林[1] 

机构地区：[1]航天医学工程研究所

出　　处：《航天医学与医学工程》1998年第4期291-293,共3页Space Medicine & Medical Engineering

摘　　要：为研究悬吊大鼠椎骨骨质内胰岛素样生长因子－Ｉ（ＩＧＦ－Ｉ）和表皮生长因子（ＥＧＦ）变化与骨代谢的关系。选用Ｓ．Ｄ．雄性大鼠２０只，按体重配对分为尾吊组和自由活动组，每组１０只，实验期２８ｄ。结果表明，悬吊大鼠第三腰椎（Ｌ３）矿盐含量显著降低，骨钙素和白蛋白含量无明显变化，ＩＧＦ－Ｉ和ＥＧＦ含量显著增加。提示：尽管骨质内骨钙素和白蛋白含量无变化，但仍发生骨矿盐丢失。骨质内细胞因子含量的增加是骨质的一种代偿反应。The aim of the study was to determine the relationship between the changes in bone metabolism and insulin-like growth factor-I(IGF-I)as well as epidermal growth factor(EGF) .10 Male S.D.rats were tail-suspended for 28 d with another 10 free active rats as control. The results showed that mineral content increased significantly, osteocalcin and albumin content had no significant change,but IGF-I and EGF content increased significantly in L3 in the suspended rats.The results suggest that although there are no change in osteocalcin and albumin content, the phenomenon of bone mineral loss still exists in the suspended rats. The increase in IGF-I and EGF content may be one of the compensation responses of the bone in the suspended rats.

关 键 词：失重模拟 骨骼脱负荷 表皮生长因子 骨代偿 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]