Immunosuppressive effects of intravenous self administration of dihydroetorphine on lymphocyte funct  

Immunosuppressive effects of intravenous self administration of dihydroetorphine on lymphocyte functions in rats 1

作　　者：吴蔚然[1,2,3] 郑继旺[1,2,3] 李凤源[1,2,3] 李颖 

机构地区：[1]西安医科大学药理教研室 [2]北京医科大学中国药物依赖性研究所 [3]北京医科大学免疫教研室

出　　处：《中国药理学报》1998年第4期387-390,共4页Acta Pharmacologica Sinica

摘　　要：Ｉｍｍｕｎｏｓｕｐｐｒｅｓｓｉｖｅｅｆｅｃｔｓｏｆｉｎｔｒａｖｅｎｏｕｓｓｅｌｆａｄｍｉｎｉｓｔｒａｔｉｏｎｏｆｄｉｈｙｄｒｏｅｔｏｒｐｈｉｎｅｏｎｌｙｍｐｈｏｃｙｔｅｆｕｎｃｔｉｏｎｓｉｎｒａｔｓ１ＷＵＷｅｉＲａｎ２，ＺＨＥＮＧＪｉＷａｎｇ３，...AIM: To study the effects of dihydroetorphine (DHE) on lymphocyte functions in rats and to further assess the abuse potential of DHE. METHODS: An intravenous self administration (SA) procedure in rats was used to determine the SA liability of DHE. Concanavalin A (Con A) stimulated lymphocyte proliferation and lympho￣kine production of rat splenocytes were measured. RESULTS: DHE 178±13 μg established a stable and typical rat model of psychological dependence, suppressed lympho￣cyte prolifera￣tion (129±11 Bq) compared with control group (620±36 Bq), and inhibited the activity of interleukin 2 (IL 2) ( A 570 =0 28±0 06) compared with control group ( A 570 =0 51±0 03). CONCLUSION: DHE had a high abuse potential and inhibited the Con A induced lymphocyte proliferation and interleukin 2 production in rats.

关 键 词：二氢埃托啡 自身给药 淋巴细胞 免疫抑制 

分 类 号：R971.2[医药卫生—药品]