Effect of procainamide on ultrastructure of blood platelet in rabbits  

作　　者：刘连璞[1] 单春文[1] 柳息洪 肖涣才 杨淑琴[1] 

机构地区：[1]第一军医大学电镜室

出　　处：《中国药理学报》1998年第4期376-379,共4页Acta Pharmacologica Sinica

摘　　要：ＥｆｅｃｔｏｆｐｒｏｃａｉｎａｍｉｄｅｏｎｕｌｔｒａｓｔｒｕｃｔｕｒｅｏｆｂｌｏｏｄｐｌａｔｅｌｅｔｉｎｒａｂｂｉｔｓＬＩＵＬｉａｎＰｕ，ＳＨＡＮＣｈｕｎＷｅｎ１，２，ＬＩＵＸｉＨｏｎｇ，ＸＩＡＯＨｕａｎＣａｉ，ＹＡＮＧＳｈｕＱｉｎ１（Ｄｅ...AIM: To study the effect of procainamide (PA) on the ultrastructure of blood platelets. METHODS: Arachidonic acid was added to PA treated platelet rich plasma to induce platelet aggregation. The 50 nm sections were examined with a transmission electron microscope. RESULTS: PA 8 5-136 μmol·L -1 markedly inhibited changes of pseudopods, α granules, dense granules, glycogens, open canalicular system,and dense tubular system. CONCLUSION: PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.

关 键 词：普鲁卡因胺 血小板聚集 超微结构 

分 类 号：R971.2[医药卫生—药品]