Effect of Coriaria lactone on cytosolic free calcium of cultured neurons from rat cerebral cortex  

Effect of Coriaria lactone on cytosolic free calcium of cultured neurons from rat cerebral cortex 1

作　　者：朱晓峰[1] 赵西龙[1] 朱长庚[1] 王金[2] 

机构地区：[1]同济医科大学脑研究室 [2]南京大学配位化学国家重点实验室

出　　处：《中国药理学报》1998年第4期336-338,共3页Acta Pharmacologica Sinica

摘　　要：ＥｆｅｃｔｏｆＣｏｒｉａｒｉａｌａｃｔｏｎｅｏｎｃｙｔｏｓｏｌｉｃｆｒｅｅｃａｌｃｉｕｍｏｆｃｕｌｔｕｒｅｄｎｅｕｒｏｎｓｆｒｏｍｒａｔｃｅｒｅｂｒａｌｃｏｒｔｅｘ１ＺＨＵＸｉａｏＦｅｎｇ２，ＺＨＡＯＸｉＬｏｎｇ３，ＺＨＵＣｈａｎｇＧｅｎｇ（Ｄ...AIM: To study the effect of Coriaria lactone (CL) on cytosolic free calcium ([Ca 2+ ] i) of cultured neurons from cerebral cortex. METHODS: Primary neuron culture (14 d) and AR CM MIC cation measurement system were used, the [Ca 2+ ] i were measured. CL effect was observed by loading egtazic acid. RESULTS: The [Ca 2+ ] i of cultured neurons (99 4-103 4) nmol·L -1 was elevated concentration dependently by CL (25-500) μmol·L -1 ( P <0.01). This effect disappeared after loading egtazic acid 5 mmol·L -1 , but reappeared after adding CaCl 2 to 1 mmol·L -1 . CONCLUSION: The [Ca 2+ ] i of cultured neurons was elevated by CL, depending on extracellular Ca 2+

关 键 词：马桑内酯 神经元 钙 大脑皮质 

分 类 号：R971.6[医药卫生—药品]