氨噻肟酸乙酯的合成研究  

Synthesis of 2-(2-aminothiazol-4-yl)-(Z)-2-(methoxyimino) acetate

作　　者：程清蓉[1] 刘志雄[2] 周红[1] 潘志权[1] 

机构地区：[1]武汉工程大学化工与制药学院,湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074 [2]吉首大学化工学院,湖南吉首416000

出　　处：《应用化工》2009年第5期675-677,684,共4页Applied Chemical Industry

摘　　要：以去甲氨噻肟酸乙酯(DMAT)为原料,对影响反应收率的反应温度、物料配比、相转移催化剂及其用量、甲基化试剂、反应时间等因素进行了研究。最佳反应条件为:反应温度20℃,NaOH为碱性试剂,DMAT∶NaOH∶(CH3O)2SO3为1∶1.2∶1.2,四丁基碘化铵作相转移催化剂,用量为底物摩尔数的7%,硫酸二甲酯为甲基化试剂,乙醇和四氢呋喃为溶剂,反应时间约为4 h,总收率为79%。2- （ 2-Aminothiazol-4 -yl ） - （ Z ） -2- （ methoxyimino ） acetate was synthesized with ethyl-demethyl- aminothiazolyloximate as raw material. The factors affect the reaction were investigated, including the reaction temperature, reagent proportion, phase transfer catalysts, methylateds, reaction time. The optimum conditions were as follows：tempeture was 20 ℃, the mole ratio of DMAT ： NaOH ： （CH3O）2SO3 was 1 ： 1.2 ： 1.2, phase transfer catalyst was CTMAC,methylateds was DMSO,solvents was EtOH and THF, reaction time was 3 h. The yield was 79%.

关 键 词：氨噻肟酸乙酯 合成 甲基化反应 头孢菌素类抗生素 

分 类 号：TQ252.5[化学工程—有机化工]