氨氯西林栓剂含量测定方法的制定  

Assay study on suppository ampicloxacillin

作　　者：张琴[1] 杨振华[1] 

机构地区：[1]山西医科大学药物分析教研室

出　　处：《山西医学院学报》1998年第1期29-30,共2页

基　　金：山西省教委科研资助

摘　　要：采用反相高效液相色谱法，选用磺胺甲基异恶唑为内标物，氨苄西林、氯唑西钠林在１０～１００ｍｇ／Ｌ的浓度范围内，线性关系良好。相关系数分别为０９９９８、０９９９６（ｎ＝６），平均回收率分别为９８２（Ｒｓ＝１６１％，ｎ＝６）；９９２（Ｒｓ＝１２８％，ｎ＝６），该方法简单易行，重现性好，准确度高。A reversed phase high performance liquid chromatography method was used for the quantitative determination of ampicillin and cloxacillin sodium.Sulfamethoxazole was used as the internal standard.The calibration curve showed good linearity over the range of 10～100 mg/L and the average recoveries of ampicillin and cloxacillin sodium were 982%(Rs=161%,n=6) and 992%(Rs=128%,n=6) respectively.The method is simple,rapid,sensitive and accurate.

关 键 词：氨氯西林 栓剂 氨苄青霉素 氯唑青霉素钠 HPLC 

分 类 号：R978.1[医药卫生—药品] R927.2[医药卫生—药学]