复方蒿甲醚临床研究:选择剂量比例和治疗方案  

Clinical studies of the compound artemether: dosage proportion and treatment regimen trial

作　　者：刘光裕[1] 单承启[1] 焦岫卿[1] 

机构地区：[1]军事医学科学院微生物学流行病学研究所

出　　处：《军事医学科学院院刊》1998年第2期92-93,97,共3页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的：选择复方蒿甲醚的最佳剂量配比和治疗方案。方法与结果：蒿甲醚与本芴醇按１∶６或１∶５的剂量配比制成２种复方片剂，各治疗恶性疟２０例，均达临床治愈。观察２８ｄ，前者（１∶６）无一复燃，治愈率１００％；后者（１∶５）复燃４例，治愈率８０．０％。进而以１∶６的片剂，设２ｄ４次，３ｄ３次和３ｄ４次给药３种疗法，比较其临床疗效。观察２８ｄ，治愈率分别为８０．０％，７２．７％和９５．９％，其中３ｄ４次疗法的治愈率明显高于另２种疗法（Ｐ＜０．０５）。结论：蒿甲醚与本芴醇按１∶６的剂量组成复方。Objective: To select best dosage proportion and treatment regimen for the compound artemether.Methods and Results: Compound artemether is composed of artemether(A) and benflumetol(B). Two kind tablets are prepared from A and B in the dosage proportion of 1∶6 or 1∶5. Forty cases of falciparum malaria were divided into two groups and given different tablets. All patients achieved clinical cure, but in 28 day followed up, 4 cases of 1∶5 group recrudesced, while no recrudescence was seen in 1∶6 group. In addition, on the basis of 1∶6 formulation, three regimens were studied according to difference courses of treatment, i. e. 4 doses/2 d, 4 doses/3 d and 3 doses/3 d. The cure rate of 4 doses/3 d was higher than other two. Conclusion: These results show that best dosage proportion of A and B is 1∶6 and the best regimen is 4 doses/3 d.

关 键 词：抗疟药 复方蒿甲醚 恶性疟 药物疗法 剂量 

分 类 号：R978.61[医药卫生—药品] R531.305[医药卫生—药学]