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作 者:吴裕浩[1] 康荣珠[1] 陈静[1] 卢进国 杨孝枝 李忠知 李晓风 张民杰
机构地区:[1]上海第二医科大学附属新华医院,上海200092 [2]湖北省潜江市计划生育服务中心,潜江433100
出 处:《生殖与避孕》1998年第3期148-153,共6页Reproduction and Contraception
基 金:国家计划生育委员会课题
摘 要:本研究把“复方苯酚糊剂”配方中苯酚含量从 35%降至25%和15%,进行动物和临床研究,观察输卵管组织变化,术后副反应和绝育效果.家兔实验发现,15%苯酚配方对输卵管粘膜破坏程度和组织反应比25%和35%苯酚配方明显轻.临床研究,15%组458例,25%组498例,随访二年.术后发热率,15%苯酚配方组仅3.7%,25%组 6.83%,有显著差异(P<0.05).腹痛发生率,15%配方组为10.26%,25%组38.35%,两组有显著差异(P<0.05),其他腰痛等副反应发生率都以15%配方组为低.15%和25%两组不同苯酚含量配方组的绝育效果无差异,分别为99.77和99.37.研究结果表明含15%苯酚的“复方苯酚糊剂”,副反应轻微而绝育效果满意,故可定为最佳配方.Phenol - Atabrine Paste (PAP) content of phenol is 35% in formulations. This study decreased content of phenol from 35% to 25% and 15%,and observed tissue reactions of oviducts, side effects and sterilization efficacy after operation.The results are as follows:The extent of oviductal mucosa destruction and tissue reaction, the 15% phenol group was obviously lower than in the 25% phenol groups. The fever reaction after operation in the 15% phenol group (458 subjects) was only 3. 7% ,and in the 25% group (498 subjects) 6. 83%,there being significant different (P<0. 05). The lower abdominal pain rate in the 15% phenol group was 10. 26% and in the 25% phenol group was 38. 35%,meaning were significant differences (P<0. 05). The sterilization efficacy was the same and the two different phenol formulation groups had 99. 77% and 99. 37% respectively. The result showed that the PAP of 15% phenol content had slight side effects and satisfying sterilization efficacy,so it is an optimal formulation.
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