缓释氟粘贴片体外抗龋和再矿化的潜力  

ANTICARIES AND REMINERALIZATION POTENTIALITYOF SLOWRELEASE FLUORIDE TABLET IN VITRO

作　　者：葛瑶[1] 王勤[1] 

机构地区：[1]北京医科大学口腔医学院防龋研究室

出　　处：《北京医科大学学报》1998年第3期249-251,共3页Journal of Peking University(Health Sciences)

基　　金："八五"国家科技攻关项目

摘　　要：目的：了解缓释氟粘贴片体外的抗龋和再矿化潜力。方法：将不同面积（１２、２４、４８、９６ｍｍ２）健康的和有人工龋的釉质块放在同样条件不同体外滴定系统的中瓶内，每个系统每４ｈ投入１片缓释氟粘贴片，共３０片。实验中不同阶段，取中瓶内人工唾液测定氟、钙、磷离子浓度，测定标本硬度值，实验后取出釉质块制作磨片，观察釉质结构的变化。分析不同实验阶段各组标本硬度值与牙外环境中钙、磷、氟浓度的变化。结果：不同滴定系统内，不同实验阶段各组标本硬度值之间无显著性差异；牙外环境中的钙、磷、氟浓度无明显不同；标本病变区的再矿化现象和抗龋能力也无明显区别。结论：该缓释氟粘贴片体外抗龋和再矿化潜力很大，即在本实验条件下，连续给３０片氟粘贴片，最大限度能控制９６ｍｍ２大小的釉面，预计能够满足临床的需要。Objective: To evaluate the anticaries and remineralizing effects of the slowrelease fluoride tablet. Methods: The normal enamel and enamal with artificial caries were put into the middle bottles of four titrate systems under the same conditions. The whole area of enamel pieces was different in every system. Each of thirty slowrelease fluoride tablets was put into the middle bottle every 4 hours. The concentration of fluoride, calcium and phosphate ions in artifical saliva was determined. The hardness of enamel was measured. The histology changes of the enamel pieces were detected. Results: There was no difference among every enamel group. Conclusion: The anticaries and remineralization potentiality of the slowrelease fluoride tablet can control the enamel area of 96　mm^2. The tablet can meet the clinical demands.

关 键 词：龋齿 预防 控制 牙再矿化 缓释氟粘贴片 

分 类 号：R988.2[医药卫生—药品] R780.1[医药卫生—药学]