苯乙烯对接触男工肾功能影响的研究  

EFFECTS OF STYRENE ON KIDNEY FUNCTION AMONG MALE WORKERS

作　　者：梁婕[1] 周乃根[1] 肖国兵[1] 马藻骅[1] 周承来[2] 

机构地区：[1]浙江省宁波市卫生防疫站,315010 [2]浙江省鄞县卫生防疫站,315010

出　　处：《职业卫生与应急救援》1998年第2期57-59,共3页Occupational Health and Emergency Rescue

摘　　要：目的：探讨苯乙烯对男工肾功能影响。方法：收集36名接触苯乙烯男工和27名不接触苯乙烯对照组的尿液，用放射免疫法测尿中白蛋白、免疫球蛋白、铁蛋白、α1-微球蛋白、β2-微球蛋白。结果：接触男工尿Alb、IgG、Fer、α1-MG和β2-MG分别为8．83±3．54μg／ml、4．87±2．62μg／ml15．79±1．07ng／ml、3．39±2．44mg／ml、52．74±2．36μg／L，对照组则分别为1．71±1．59μg／ml、1．73±1．68μg／ml、15．5±1．00mg／ml、2．47±2．10mg／L、33．06±2．09μg／ml。接触组尿Alb、IgG及α1－MG、β2－MG水平显著高于对照组（P＜0．001，P＜0．05）。接触组Alb、IgG阳性率也显著高于对照组。结论：苯乙烯的短期接触即可影响肾小球的功能，Alb、IgG和。α1－MG、β2－MG等可作为观察苯乙烯对肾功能早期损伤的敏感指标。Objective: To evaluate the effects of kidney function in styrene exposedmale workers. Methods: Urine samples were collected from 36 workers exposed tostyrene and the other 27 non-exposed workers for control. Albumin(Alb), immunoglobulin G(IgG), ferritin(Fer),α1-microglobulin(α1-MG) and β2-microglobulin (β2-MG)in urine were determined by radioimmunoassay(RIA). Results: It showed that theaverage level of Alb, IgG, Fer, α1-MG and β2-MG in urine among exposed workerswere 8.83 ± 3.54ug/ml, 4.87 ± 2.62ug/ml, 15.79 ± 1.07ng/ml, 3.39 ± 2.44mg/ml and52.74 ± 2.36ug/L,respectively. While, those among non-exposed workers were 1.71± 1.59ug/ml, 1.73 ± 1.68ug/ml, 15.5 ± 1.00ng/ml, 2.47 ± 2.10mg/L, 33.06 ± 2.09ug/ml, respectively. Mean Alb, IgG, α1-MG and β2-MG in urine of exposed workerswere significantly higher than those of control workers(P<0.001,P<0.05). However, thepercentage of abnormality of Alb and IgG increased in exposed workers. Conclusion:The styrene could affect the function of glomeruli, and Alb, IgG, α1-MG and β2-MGin urine could constitute sensitive features for early damage of kidney.

关 键 词：苯乙烯 男工 微球蛋白 肾功能 

分 类 号：R996[医药卫生—毒理学] R992[医药卫生—药学]