芪味糖平胶囊干预治疗糖耐量减低对糖尿病发病率的影响  

Effect of Qiwei Tangping Capsule(芪味糖平胶囊) for Impaired Glucose Tolerance On Incidence of Diabetes

作　　者：焦秀坤 王保群 杨立波[2] 陈雪玲 季振慧 

机构地区：[1]河北师大医院,石家庄050091 [2]河北医科大学医药研究院,石家庄050035

出　　处：《中药药理与临床》2009年第2期115-117,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：河北省科技攻关项目:项目编号062761394

摘　　要：目的:观察芪味糖平胶囊干预治疗糖耐量减低(IGT)对糖尿病(DM)发病率以及逆转为正常糖耐量(NGT)的疗效。方法:采用随机、双盲、安慰剂平行对照的试验设计方法,以口服75克葡萄糖耐量试验(OGTT)筛选,按1999年WHO诊断标准判定的100例患者进行2年前瞻性研究。初诊时患者按就诊顺序被随机分配至试验组与对照组,每组50例。试验组给予口服芪味糖平胶囊每次3粒,每日2次;对照组给予口服芪味糖平胶囊安慰剂每次3粒,每日2次。疗程24个月。结果:IGT发展为DM者芪味糖平胶囊组为4.17%,安慰剂组为25.53%;IGT转NGT者芪味糖平胶囊组为50.00%,安慰剂组为17.02%,2组比较差异具有统计学意义(P<0.01)。结论:芪味糖平胶囊治疗IGT可明显降低DM的发病率,是防止IGT向DM发展的有效措施。Objective To evaluate the effects of Qiwei Tangping Capsule on conversion to DM or NGT in IGT patients. Methods A randomized, doubleblind, placebo-controlled, parallel group trial was designed. In this 2-year prospective study, 100 subject with IGT were included. IGT was defined by 1999 WHO criteria utilizing a 75g oral glucose tolerance test（OGTY）. Subject was random divided into the trial（50 case） and control （50 case） groups. All subject werent intervened lifeway, only given IGT knowledge education. The trial group was given Qiwei Tangping Capsule at the dose of three Capsule （twice per day）, and the control group was given placebo Capsule at the dose of three Capsule （twice per day）. The study lasted for twenty-four months. Results The ratio of IGT converting to DM was 4.17% in trial group and 25.53% in control group, and the ratio of IGT converting to NGT was 50.00% in trial group and 17.02% in control group, （ P 〈 0.01 ）. Conclusion Intervention treatment with Qiwei Tangping Capsule was one of the effective measures preventing the conversion of IGT to DM.

关 键 词：糖耐量减低 糖尿病 芪昧糖平胶囊 

分 类 号：R259[医药卫生—中西医结合]