原发性先天性青光眼患者术后生活质量的评价  

Quality of life in patients with primary congenital glaucoma following antiglaucoma surgical management

作　　者：张秀兰[1] 杜绍林[1] 葛坚[1] 陈伟蓉[1] 樊倩[1] 彭寿雄[1] 余敏斌[1] 刘杏[1] 

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广州510060

出　　处：《中华眼科杂志》2009年第6期514-521,共8页Chinese Journal of Ophthalmology

基　　金：广东省科技计划项目（2008B060600028）

摘　　要：目的应用儿童和青少年眼病生活质量量表评价原发性先天性青光眼患者的生活质量。方法横断面研究。首先对5～20岁共51例原发性先天性青光眼术后患者和50例相匹配的正常对照者进行生活质量量表调查，并对量表的信度、效度及反应度进行评价；然后应用该量表对上述原发性先天性青光眼患者术后7年（中位数）末次随访时的生活质量状况进行量表调查。应用SPSS13．0统计学软件对数据进行处理。采用单因素相关分析和多因素逐步回归分析方法评价生活质量得分情况及其与疾病类型、病情严重程度、手术疗效、术后视力、年龄、性别、性格等关系。结果量表共由23个条目组成，经评定具有较好的信度、效度及反应度；23个条目完全符合原发性先天性青光眼患者生活质量的评价要求。原发性先天性青光眼患者的生活质量量表总分60．02±10．02，比正常对照者的总分（71．41±0．11）明显偏低（t=5．682，P=0．000）。单因素相关分析结果表明，病情严重程度（F=24．026，P=0．000）、手术疗效（t=2．638，P=0.009）及术后视力分级（F=11．248，P=0．000）均与生活质量总分相关，病情严重程度（F=12．677，P=0．000）和术后视力分级（F=10．369，P=0．000）与视功能领域得分相关，病情严重程度（F=11．064，P=0．000）和手术疗效（t=2．297，P=0．042）与自理能力领域得分相关；病情严重程度（F=6．869，P=0．020；F=5．721，P=0．019）和性格特征（t=4．352，P=0．009；t=2．297，P=0．042）均与活动交往和精神心理领域得分相关。多因素逐步回归分析结果表明，量表总分和患者病情严重程度（β=-6．985，P=0．001）、术后视力分级（β=-4．978，P=0．003）及性格（β=-5．201，P=0．020）之间均存在明显负相关。结论该量表符合生活质量量表效度、信度、反应度及易于分析的技术要求Objective To evaluate the 23-item scale of Quality of Life （QOL） for patients with primary congenital glaucoma （PCG）. Methods It was a cross-sectional study. The QOL scale specific for patients with PCG was firstly evaluated on 51 patients with PCG following antiglaucomat surgery at last follow- up visit （7. 80 years± 2. 93 years with a median at 7 years ） and 50 participants with normal visual acuity （VA） as control. All participants were aged 5-20 years old. The QOL of PCG was evaluated with type of disease, severity, surgical outcome, postoperative VA, age, gender and personality by using single-factor correlation analysis and multiple-factor stepwise regression analysis. Results The PCG-QOL scale achieved good reliability, validity and responsibility for PCG and 23-item were all qualified for QOL evaluation of PCG. The total scores of QOL in patients with PCG were significantly lower than those of normal individuals （PCG 60. 22 ± 10. 02,normal individuals 71.41 ± 10. 11 ;t =5. 682, P =0. 000）. Single-factor correlation analysis showed that the total scores of QOL were associated significantly with the severity of glaucoma （ F = 24. 026, P =0. 000）, surgical outcome （t =2. 638, P =0. 009） and postoperative VA （F = 11. 248, P = 0. 000 ） ; The visual function scores were associated significantly with the severity （F= 12. 677, P = 0. 000 ） and postoperative VA （ F = 10. 369, P = 0. 000） ; The self-care ability scores were associated significantly with the severity （ F = 11. 064, P = 0. 000 ） and surgical outcome （ t = 2. 297, P = 0. 042 ） ; The social and mental scores were all correlated significantly with the severity （ F = 6. 869, P = 0. 020; F = 5. 721, P = 0. 019） and personality （t = 4. 352, P=0. 009; t = 2. 297, P = 0. 042）. Multiple-factor stepwise regression analysis showed that there were significant correlations between total scores and the severity （ 13 = - 6. 985, P = 0. 001 ）, postoperative VA （ 13 = - 4. 978, P = 0. 003 ） and person

关 键 词：青光眼 生活质量 疾病影响状态调查 

分 类 号：R686[医药卫生—骨科学]