胃舒散对实验性胃炎保护作用的研究  

Protective Effect of Weishu Powder on Experimental Acute Gastritis in Rat

作　　者：林旭楷[1] 肖咏[1] 韩坚[2] 潘怀耿[3] 张奕鹏[1] 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041 [2]广州中医药大学中药学院药理研究室,广东广州510405 [3]广州中医药大学脾胃研究所,广东广州510405

出　　处：《中国实验方剂学杂志》2009年第6期47-49,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察胃舒散对实验性急性胃炎的保护作用。方法:采用不同剂量灌胃给药,观察胃舒散对乙醇致大鼠实验性胃炎和醋酸致小鼠扭体反应的影响,并与同剂量的陈香露白露片进行比较。结果:胃舒散和陈香露白露片组均能明显降低乙醇致胃粘膜损伤和水杨酸钠诱发的大鼠急性胃炎模型的溃疡指数,降低醋酸致小鼠发生扭体反应的次数(与空白组比较P<0.05或P<0.01);而陈香露白露片高、低剂量组与胃舒散同等剂量组的作用差异明显(P<0.05orP<0.01)。结论:胃舒散对乙醇致胃粘膜损伤和水杨酸钠诱发的大鼠急性胃炎有明显的保护作用,并能显著抑制醋酸诱发的小鼠扭体反应次数,且胃舒散作用强于同剂量的陈香露白露片。Objective： To observe the protective effect of Weishu Powder （WP） on experimental acute gastritis in rat. Methods： fifty-six SD rats were randomized into normal group, model group, low-dose WP group, high-dose WP group,low-does Chen-xiang-lu-bai-lu tablet （Chen） group, high-dose Chen group and Cimetidine group. The rats in the above groups were fed with the corresponding drugs by gastric infusion for 3 days. The injury of stomach mucous membrane induced by alcohol and acute gastritis induced by sodium salicylate in rats were observed. Effect of WP on the count of somatic wrenching reaction induced by dilute acetic acid in mice were determined. Results： As compared with the model group, two dose groups of WP could depress the injury of stomach mucous membrane induced by, alcohol and reduce the ulceration index of acute gastritis induce by sodium salicylate （P 〈 0.05 or P 〈 0.01 ）, also decreased the count of somatic wrenching reaction in mice. The different effects between WP and Chen in the same dose was significant （ P 〈 0.05 or P 〈 0.01）. Conclusion： WP possess markedly protective effect on the injury of stomach mucous membrane in rat, it also reduced the wrenching count in mice. The effect of WP was superior to Chen in the same dose.

关 键 词：胃舒散 急性胃炎 扭体反应 大鼠 

分 类 号：R285.5[医药卫生—中药学]