葛根素和葛根黄酮的药代动力学研究概述  

A Brief Review on Herbal Pharmacokinetics Study for Puerarin and Flavone of Radix puerariae lobatae

作　　者：郭宇洁[1] 孟硕[1] 徐辉[1] 刘建勋[1] 

机构地区：[1]中国中医科学院西苑医院实验中心,北京100091

出　　处：《中国实验方剂学杂志》2009年第6期82-85,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：中药的作用特点是多成分、多途径、多靶点,中药药代动力学的研究是中药研究的关键技术之一。葛根的主要有效成分和有效部位为葛根素及葛根黄酮,该文从生物样品预处理、样品测定、葛根素及葛根黄酮在体内的吸收、分布、代谢排泄和药动学参数等方面着手,对葛根素和葛根黄酮的药代动力学研究进行综述,认为应加强正常和病理状态下葛根素和葛根黄酮在脑脊液及脑组织中的分布和代谢研究,为临床脑血管疾病以及相关疾病的治疗提供用药指导。The action principles of Chinese traditional medicines feature multi-active components, multi-paths, multi-target sites. One of the key points in Chinese traditional medicine research is the study of herbal pharmacokinetics. The chief active constituent and effective part of Radix puerariae lobatae are puerarin and flavone. The pharmacokinetics researches for the two components are summed up, including biological specimen pretreatment, sample identification, absorption, distribution, metabolism and excretion in vivo.

关 键 词：葛根素 葛根黄酮 药代动力学 

分 类 号：R285.5[医药卫生—中药学]